Merck
CN

ABAT

4-aminobutyrate aminotransferase

别名:
GABA-AT, GABAT, NPD009
物种:
Human ABAT (18), Mouse Abat (268860), Rat Abat (81632), Horse ABAT (100051470), cow ABAT (280969), sheep ABAT (101105462), Goat ABAT (100861058), domestic guinea pig Abat (100725419), domestic cat ABAT (101089064), naked mole-rat Abat (101712584) ...展开
UniProtKB ID:
P80404, A8K386, Q16260, Q8N5W2, Q96BG2, Q99800
基因ID:
  • Human(18) Summary: 4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95% similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008]
  • Mouse(268860) 4-aminobutyrate aminotransferase
  • Rat(81632) 4-aminobutyrate aminotransferase
  • Horse(100051470) 4-aminobutyrate aminotransferase
  • cow(280969) 4-aminobutyrate aminotransferase
  • sheep(101105462) 4-aminobutyrate aminotransferase
  • Goat(100861058) 4-aminobutyrate aminotransferase
  • domestic guinea pig(100725419) 4-aminobutyrate aminotransferase
  • domestic cat(101089064) 4-aminobutyrate aminotransferase
  • naked mole-rat(101712584) 4-aminobutyrate aminotransferase
  • chicken(416642) 4-aminobutyrate aminotransferase
  • Zebrafish(378968) 4-aminobutyrate aminotransferase
  • dog(479856) 4-aminobutyrate aminotransferase

Custom & Knockdown Gene Products

  • siRNA

    Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.

  • shRNA

    Shop the largest, most validated shRNA collection and build your own clone sets.

  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.

Antibodies

货号
说明
物种反应性
应用
SAB5702893
Anti-GABA transaminase (ABAT) Antibody, clone 10V1K9, Rabbit Monoclonal, ,
物种反应性
human, rat
应用
immunohistochemistry
western blot
HPA041690
Anti-ABAT antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
物种反应性
human
应用
immunohistochemistry
western blot
SAB2100006
Anti-ABAT antibody produced in rabbit, affinity isolated antibody,
物种反应性
bovine, dog, goat, guinea pig, human, mouse, rabbit, rat
应用
western blot
HPA041528
Anti-ABAT antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
物种反应性
human
应用
immunohistochemistry
western blot

Small Molecule - Inhibitor

货号
说明
物种
1712001
(±)-Vigabatrin, United States Pharmacopeia (USP) Reference Standard,
物种
human
V-022
Vigabatrin solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®,
物种
human
BP563
(±)-Vigabatrin, British Pharmacopoeia (BP) Reference Standard,
物种
human
Y0001400
氨己烯酸, European Pharmacopoeia (EP) Reference Standard,
物种
human
V8261
(±)-Vigabatrin, ,
物种
human

esiRNA

货号
说明
物种
EMU217131
MISSION® esiRNA, targeting mouse Abat,
物种
mouse
EMU015101
MISSION® esiRNA, targeting mouse Abat,
物种
mouse
EHU001161
MISSION® esiRNA, targeting human ABAT,
物种
human