想提高下游工艺效率吗？
生物制造工作流的转型正加速推进，这源于对新型疗法的需求，同时需要在确保运营灵活性和生产力的前提下降低成本。
工艺强化、封闭式及连续生物加工是实现这些目标的基础策略。这些技术已在下游处理系统中广泛成功应用，显著提升了效率、速度、设备小型化、成本控制及可持续性。
为助力生物制药企业实现工艺强化、封闭化、数字化升级或全面连续化转型，从而获得更高运营效率与灵活性，DSP套件内置多重优化手段。
捕获色谱
捕获色谱步骤不仅是成本的主要来源，还可能成为整个下游处理（DSP）工作流程的瓶颈。通过采用连续多柱色谱技术，可显著优化这一下游纯化步骤：在提高单克隆抗体工艺产量的同时，大幅减少所需蛋白A树脂的用量及相关成本。
高结合容量、卓越流速性能、可重复使用且制造成本低的蛋白A树脂，对工艺强化同样至关重要。
- Mobius®多柱捕获系统是一款全自动一次性三柱系统，适用于分批补料或灌流生物工艺的连续封闭捕获色谱。
- Eshmuno® A树脂是一种刚性、高容量的蛋白A亲和色谱树脂，可在酸碱条件下进行清洗和消毒，同时在高流速下保持高动态结合容量。
相关分类
一次性与可重复使用色谱系统对贵重分子的分离至关重要。
亲和层析常用于捕获阶段，以分离目标分子并减少工艺体积。
离子交换色谱（IEX）通过目标分子与色谱树脂之间的电荷差异来分离生物分子。
采用膜色谱技术优化下游纯化流程，实现捕获与精制。Natrix膜技术显著提升经济效益与设施效率。
提升过滤精度：我们的切向流产品确保单克隆抗体、疫苗等制剂的纯度，可从一次性使用扩展至多次使用。
相关资源
- Article: What is Multi Column Chromatography?
In this article, we will discuss one of the methods used to intensify the capture chromatography process: multi column chromatography (MCC).
- Data Sheet: Mobius® Multi Column Capture System
The Mobius® Multi Column Capture system is designed as a fully automated, single-use solution to operate continuous closed capture chromatography.
- Application Note: Efficient Protein A Capture in Intensified Processes: Process Characterization and Scalability
Assess the efficiency of continuous mAb capture from a clarified and filtered harvest cell culture fluid (HCCF), using the Mobius® Multi Column Capture system and evaluate process scalability.
- Application Note: Multi-Column Chromatography for Efficient Polishing Purification
The studies in this application note focus on Ion Exchange (IEX) chromatography in bind/elute mode using the Mobius® Multi Column Capture system.
- Application Note: Multi Column Capture
Results from the multi-column capture (MCC) system implementation as part of a fully integrated downstream continuous manufacturing platform are reported here.
- Application Note: Intensified Polishing Using Single-Pass Tangential Flow Filtration (SPTFF) with Anion Exchange Chromatography
In this app note, SPTFF preconcentration is used to intensify the anion exchange (AEX) polishing step in monoclonal antibody (mAb) processing for improved impurity removal and column productivity.
- Application Note: Implementation of Multi-Column Chromatography Systems
The Multi-Column Capture (MCC) System enables efficient primary capture through three column operation, supporting continuous feedstream processing.
相关网络研讨会
提高流程效率并降低成本。
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