捕获色谱法
捕获层析步骤不仅对成本有重大影响，而且可能成为整个 DSP（下游加工）工作流程的瓶颈。使用连续多柱色谱法可以优化这一下游纯化步骤，从而大大减少所需的蛋白 A 树脂量和相关成本，同时提高 mAb 工艺的生产率。
- Mobius®多柱捕获系统，这是一种全自动、一次性使用的 3 柱系统，用于对您的供料批次或灌流生物工艺进行连续封闭捕获色谱分析。
- Eshmuno® A 树脂。，一种硬质、高容量的蛋白 A 亲和色谱树脂，可在酸性和碱性条件下进行清洗和消毒，同时在高流速下保持高动态结合能力。
相关类别
单用途和多用途色谱系统对于分离贵重分子至关重要。
亲和层析通常用于捕获阶段，以分离目标分子并减少处理量。
离子交换（IEX）色谱法根据目标分子和色谱树脂之间的电荷差来分离生物分子。
利用膜色谱捕获和抛光优化下游纯化。Natrix 膜提高了经济效益和设备效率。
提高过滤精度：我们的切向流产品可确保 mAbs、疫苗等产品的纯度，从一次性使用扩展到多次使用。
相关资源
- Article: What is Multi Column Chromatography?
In this article, we will discuss one of the methods used to intensify the capture chromatography process: multi column chromatography (MCC).
- Data Sheet: Mobius® Multi Column Capture System
The Mobius® Multi Column Capture system is designed as a fully automated, single-use solution to operate continuous closed capture chromatography.
- Application Note: Multi Column Capture
Results from the multi-column capture (MCC) system implementation as part of a fully integrated downstream continuous manufacturing platform are reported here.
- Application Note: Intensified Polishing Using Single-Pass Tangential Flow Filtration (SPTFF) with Anion Exchange Chromatography
In this app note, SPTFF preconcentration is used to intensify the anion exchange (AEX) polishing step in monoclonal antibody (mAb) processing for improved impurity removal and column productivity.
- Application Note: Implementation of Multi-Column Chromatography Systems
The Multi-Column Capture (MCC) System enables efficient primary capture through three column operation, supporting continuous feedstream processing.
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