流动抛光色谱法
抛光层析发生在 mAb 病毒灭活后的下游加工过程中，目的是去除单克隆抗体原料流中的任何残留杂质。在传统的间歇工艺中，抛光步骤占生产成本的近 25%。将单个抛光步骤整合到单一的连续流动工艺中，可提高效率和产量，同时降低高达 10% 的成本。这种强化方法通过消除中间储罐、减少缓冲消耗和去除产品稀释步骤来降低总体占地面积。
- Eshmuno®，设计用于在流过式正面层析操作模式下高效去除 mAb 聚集，使装载能力比传统的结合/消光 CEX 层析高 10 倍。
- Natrix®，一种高容量、高通量的强阴离子交换膜吸附器，设计用于在流动操作条件下纯化生物分子。
相关类别
单用途和多用途色谱系统对于分离贵重分子至关重要。
亲和层析通常用于捕获阶段，以分离目标分子并减少处理量。
离子交换（IEX）色谱法根据目标分子与色谱树脂之间的电荷差来分离生物分子。
利用膜色谱捕获和抛光优化下游纯化。Natrix 膜提高了经济效益和设备效率。
提高过滤精度：我们的切向流产品可确保 mAbs、疫苗等产品的纯度，从一次性使用扩展到多次使用。
相关资源
- Flow-Through Polishing Process Development: A Holistic Approach
In this white paper, we describe development and evaluation of a flow-through polishing step, which is critical for the evolution towards a continuous process.
- What is Multi Column Chromatography?
In this article, we will discuss one of the methods used to intensify the capture chromatography process: multi column chromatography (MCC).
- Mobius® Multi Column Capture System
The Mobius® Multi Column Capture system is designed as a fully automated, single-use solution to operate continuous closed capture chromatography.
- App Note: Multi Column Capture
Results from the multi-column capture (MCC) system implementation as part of a fully integrated downstream continuous manufacturing platform are reported here.
- Intensified Polishing Using Single-Pass Tangential Flow Filtration (SPTFF) with Anion Exchange Chromatography
In this app note, SPTFF preconcentration is used to intensify the anion exchange (AEX) polishing step in monoclonal antibody (mAb) processing for improved impurity removal and column productivity.
相关网络研讨会
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