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Merck
CN

P1742

前白蛋白 来源于人类血浆

lyophilized powder

别名:

甲状腺素结合前白蛋白, 甲状腺素运载蛋白

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关于此项目

化学文摘社编号:
UNSPSC Code:
12352202
NACRES:
NA.25
MDL number:
Biological source:
human plasma
Assay:
≥95% (SDS-PAGE)
Form:
lyophilized powder
Technique(s):
immunoelectrophoresis: suitable, immunoprecipitation (IP): suitable
Impurities:
Infectious agents, tested
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biological source

human plasma

assay

≥95% (SDS-PAGE)

form

lyophilized powder

technique(s)

immunoelectrophoresis: suitable, immunoprecipitation (IP): suitable

impurities

Infectious agents, tested

solubility

H2O: soluble 1 mg/mL

ε (extinction coefficient)

13.5 at 280 nm at 1%

UniProt accession no.

storage temp.

−20°C

Quality Level

Gene Information

human ... TTR(7276)

General description

人前白蛋白是18号染色体的产物。它是一种血清蛋白,主要在肝脏中合成。 它是一种四聚体蛋白,分子量为55 kDa。人前白蛋白由非共价结合的四个相同的单体(127个氨基酸残基)组成,排列成对称的四面体。

Application

人前白蛋白用于研究肺癌血清中甲状腺素运载蛋白表达的下调。
前白蛋白(来自人血浆)已用作免疫沉淀的阳性对照作为火箭免疫电泳法定量分析脑脊液的参考标准品。

Biochem/physiol Actions

人前白蛋白可在类癌瘤中观察到。
前白蛋白水平是营养不良的指示剂,而且可能受到炎症反应调节。在慢性肾衰竭患者的透析期间,它被视为蛋白质能量营养不良(PEM)的潜在标志物。低水平的前蛋白会导致心脏衰竭(HF)风险提高。

Packaging

包装规格基于蛋白含量

Physical form

含有磷酸钠和NaCl的冻干粉

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

常规特殊物品
此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Haruki Koike et al.
Journal of neurology, 255(10), 1526-1533 (2008-09-30)
Through the development of gene diagnostic techniques, late-onset transthyretin Met30-associated familial amyloid polyneuropathy (FAP TTR Met30) has been shown to be more prevalent than is generally believed. To examine the electrophysiological features of late-onset FAP TTR Met30 unrelated to endemic
Prealbumin is as important as albumin in the nutritional assessment of hemodialysis patients
Chertow GM, et al.
Kidney International, 58(6), 2512-2517 (2000)
K Nelson et al.
International journal of cancer, 15(5), 806-814 (1975-05-15)
Spleen cells from BALB/c mice which either bore syngeneic sarcomas or were normal controls were cultured in vitro. The culture supernatants of spleen cells from tumor-bearing mice inhibited (blocked) specific cell-mediated cytotoxicity to the tumor borne by the spleen donor.
A combined biomarker pattern improves the discrimination of lung cancer
Liu L, et al.
Biomarkers, 16(1), 20-30 (2011)
Takashi Ito et al.
Internal medicine (Tokyo, Japan), 45(20), 1173-1175 (2006-11-16)
Previously no functional study has been available for the mechanism of constipation in familial amyloid polyneuropathy (FAP). We performed a gut function test in a 78-year-old woman with transthyretin-type FAP who had severe constipation. The gut function test showed a

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