12804
苯并三氮唑-N,N,N′,N′-四甲基脲六氟磷酸酯
≥98.0% (T), for peptide synthesis
别名:
N,N,N′,N′-四甲基-O-(1H-苯并三氮唑)六氟磷酸脲, HBTU
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关于此项目
经验公式（希尔记法）:
C11H16F6N5OP
化学文摘社编号:
分子量:
379.24
Beilstein:
7328329
EC 号:
MDL编号:
UNSPSC代码:
12352107
PubChem化学物质编号:
NACRES:
NA.22
产品名称
苯并三氮唑-N,N,N′,N′-四甲基脲六氟磷酸酯, ≥98.0% (T)
质量水平
方案
≥98.0% (T)
表单
solid
反应适用性
reaction type: Coupling Reactions
mp
200 °C (dec.) (lit.)
溶解性
acetonitrile: 0.1 g/mL, clear
应用
peptide synthesis
官能团
amine
储存温度
2-8°C
SMILES字符串
F[P-](F)(F)(F)(F)F.CN(C)C(\On1nnc2ccccc12)=[N+](/C)C
InChI
1S/C11H16N5O.F6P/c1-14(2)11(15(3)4)17-16-10-8-6-5-7-9(10)12-13-16;1-7(2,3,4,5)6/h5-8H,1-4H3;/q+1;-1
InChI key
UQYZFNUUOSSNKT-UHFFFAOYSA-N
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一般描述
HBTU是一种肽偶联剂，用于基于Fmoc的固相肽合成。
应用
HBTU是用于多肽合成的多肽偶联剂。它也被用于标准Fmoc固相多肽合成（SPPS）方案。
最近研究显示，这种偶联试剂的结晶或溶液结构是胍的 N-氧化物形式，,而不是脲化合物； 用于多肽合成的偶联试剂；优点是：极低的外消旋化，简单的反应条件，非常短的反应时间和高产率。
警示用语：
Warning
危险声明
危险分类
Skin Sens. 1A
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
Héloise Boullet et al.
Molecules (Basel, Switzerland), 24(9) (2019-05-06)
Antimicrobial peptides (AMPs) are considered as potential therapeutic sources of future antibiotics because of their broad-spectrum activities and alternative mechanisms of action compared to conventional antibiotics. Although AMPs present considerable advantages over conventional antibiotics, their clinical and commercial development still
Mark Lommel et al.
Scientific reports, 8(1), 11753-11753 (2018-08-08)
Thrombospondins (TSPs) are multidomain glycoproteins with complex matricellular functions in tissue homeostasis and remodeling. We describe a novel role of TSP as a Wnt signaling target in the basal eumetazoan Hydra. Proteome analysis identified Hydra magnipapillata TSP (HmTSP) as a
Marc-Philipp Pfeil et al.
Scientific reports, 8(1), 14926-14926 (2018-10-10)
The spread of antimicrobial resistance stimulates discovery strategies that place emphasis on mechanisms circumventing the drawbacks of traditional antibiotics and on agents that hit multiple targets. Host defense peptides (HDPs) are promising candidates in this regard. Here we demonstrate that
L P Miranda et al.
Proceedings of the National Academy of Sciences of the United States of America, 96(4), 1181-1186 (1999-02-17)
The chemical synthesis of peptides and small proteins is a powerful complementary strategy to recombinant protein overexpression and is widely used in structural biology, immunology, protein engineering, and biomedical research. Despite considerable improvements in the fidelity of peptide chain assembly
The uronium/guanidinium peptide coupling reagents: finally the true uronium salts.
Carpino LA, et al.
Angewandte Chemie (International Edition in English), 41(3), 441-445 (2002)
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