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Merck
CN

12804

苯并三氮唑-N,N,N′,N′-四甲基脲六氟磷酸酯

≥98.0% (T), for peptide synthesis

别名:

N,N,N′,N′-四甲基-O-(1H-苯并三氮唑)六氟磷酸脲, HBTU

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关于此项目

经验公式(希尔记法):
C11H16F6N5OP
化学文摘社编号:
分子量:
379.24
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352107
EC Number:
423-020-5
MDL number:
Beilstein/REAXYS Number:
7328329
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产品名称

苯并三氮唑-N,N,N′,N′-四甲基脲六氟磷酸酯, ≥98.0% (T)

Quality Level

assay

≥98.0% (T)

form

solid

reaction suitability

reaction type: Coupling Reactions

mp

200 °C (dec.) (lit.)

solubility

acetonitrile: 0.1 g/mL, clear

application(s)

peptide synthesis

functional group

amine

storage temp.

2-8°C

SMILES string

F[P-](F)(F)(F)(F)F.CN(C)C(\On1nnc2ccccc12)=[N+](/C)C

InChI

1S/C11H16N5O.F6P/c1-14(2)11(15(3)4)17-16-10-8-6-5-7-9(10)12-13-16;1-7(2,3,4,5)6/h5-8H,1-4H3;/q+1;-1

InChI key

UQYZFNUUOSSNKT-UHFFFAOYSA-N

General description

HBTU是一种肽偶联剂,用于基于Fmoc的固相肽合成。

Application

HBTU是用于多肽合成的多肽偶联剂。它也被用于标准Fmoc固相多肽合成(SPPS)方案。
最近研究显示,这种偶联试剂的结晶或溶液结构是胍的 N-氧化物形式,,而不是脲化合物; 用于多肽合成的偶联试剂;优点是:极低的外消旋化,简单的反应条件,非常短的反应时间和高产率。


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pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Skin Sens. 1A

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves



历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Kaido Kurrikoff et al.
Scientific reports, 7(1), 17056-17056 (2017-12-08)
Non-viral gene delivery systems have gained considerable attention as a promising alternative to viral delivery to treat diseases associated with aberrant gene expression. However, regardless of extensive research, only a little is known about the parameters that underline in vivo
Structural studies of reagents for peptide bond formation: Crystal and molecular structures of HBTU and HATU.
Abdelmoty I, et al.
Lett. Pept. Sci., 1(2), 57-67 (1994)
Allan Bastos Lima et al.
Bioorganic & medicinal chemistry, 23(17), 5748-5755 (2015-08-04)
Dengue virus (DENV) and West Nile virus (WNV) are mosquito-borne arboviruses responsible for causing acute systemic diseases and severe health conditions in humans. The discovery of therapies capable to prevent infections or treat infected individuals remains an important challenge, since



全球贸易项目编号

货号GTIN
195324-5G04061833320488
12804-25G-F04061838725325
12804-5G-F04061838725332
12804-1G-F04061838725318