质量水平
方案
98%
表单
powder
旋光性
[α]19/D +90°, c = 0.5 in KH2PO4/trace NaOH
反应适用性
reaction type: solution phase peptide synthesis
mp
>300 °C (lit.)
抗生素抗菌谱
Gram-positive bacteria
应用
peptide synthesis
作用机制
cell wall synthesis | interferes
储存温度
2-8°C
SMILES字符串
[H][C@]12SCC(COC(C)=O)=C(N1C(=O)[C@H]2N)C(O)=O
InChI
1S/C10H12N2O5S/c1-4(13)17-2-5-3-18-9-6(11)8(14)12(9)7(5)10(15)16/h6,9H,2-3,11H2,1H3,(H,15,16)/t6-,9-/m1/s1
InChI key
HSHGZXNAXBPPDL-HZGVNTEJSA-N
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一般描述
化学结构:β-内酰胺
应用
7-氨基头孢烷酸（7-ACA）可用作制备以下物质的原料：
- 在三乙胺存在的情况下与 S-苯并噻唑-2-基（2-氨基-4-噻唑基）（甲氧基亚氨基）硫代乙酸酯 （MAEM）反应合成的头孢噻肟 。
- 通过头孢噻肟中间体合成的第三代抗生素头孢泊肟酯。
- 作为β-内酰胺酶潜在抑制剂的3′-取代头孢菌素钠砜衍生物。
细菌（金黄色葡萄球菌）β-内酰胺酶的有效抑制剂。
警示用语：
Danger
危险声明
危险分类
Resp. Sens. 1 - Skin Sens. 1
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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Site-directed protein immobilization allows the homogeneous orientation of proteins with high retention of activity, which is advantageous for many applications. Here, we report a facile, specific, and efficient strategy based on the SpyTag-SpyCatcher chemistry. Two SpyTag-fused model proteins, that is
Synthesis and Preliminary Biological Evaluation of 3?-Substituted Cephem Sulfones as Potential β-Lactamase Inhibitors
De Angelis F, et al.
European Journal of Organic Chemistry, 2001(16), 3075-3081 (2001)
Denis L Atroshenko et al.
International journal of molecular sciences, 20(18) (2019-09-11)
d-amino acid oxidase (DAAO, EC 1.4.3.3) is used in many biotechnological processes. The main industrial application of DAAO is biocatalytic production of 7-aminocephalosporanic acid from cephalosporin C with a two enzymes system. DAAO from the yeast Trigonopsis variabilis (TvDAAO) shows
Dongxue Hu et al.
Bioresource technology, 304, 123014-123014 (2020-02-24)
In this study, a lab-scale multiple draft tubes airlift loop membrane bioreactor (Mt-ALMBR) was used for treating acidic 7-amino cephalosporanic acid (7-ACA) wastewater under different pHs (3.54-6.20) and hydraulic retention time (HRT) (48 h, 36 h, 24 h and 16 h). During about 200 days
Irene Martínez-Martínez et al.
Analytical biochemistry, 369(2), 210-217 (2007-07-27)
A bromothymol blue-based colorimetric assay has been devised to screen for acetyl xylan esterase or cephalosporin C (CPC) deacetylase activities using 7-amino cephalosporanic acid (7-ACA), CPC, or acetylated xylan as substrate. These enzymes are not screened with their natural substrates
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