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Merck
CN

248924

Sigma-Aldrich

7-氨基-4-(三氟甲氧基)香豆素

≥99%

别名:

香豆素 151

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关于此项目

经验公式(希尔记法):
C10H6F3NO2
化学文摘社编号:
分子量:
229.16
Beilstein:
4456797
EC 号:
MDL编号:
UNSPSC代码:
12171500
PubChem化学物质编号:
NACRES:
NA.47
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方案

≥99%

表单

(Powder or Crystals or Chunks)

技术

titration: suitable

mp

221-222 °C (lit.)

λmax

≤207 nm

应用

diagnostic assay manufacturing
hematology
histology

储存温度

room temp

SMILES字符串

Nc1ccc2c(OC(=O)C=C2C(F)(F)F)c1

InChI

1S/C10H6F3NO2/c11-10(12,13)7-4-9(15)16-8-3-5(14)1-2-6(7)8/h1-4H,14H2

InChI key

JBNOVHJXQSHGRL-UHFFFAOYSA-N

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一般描述

7-氨基-4-(三氟甲基)香豆素(AFC)是用于检测蛋白酶的一种新型荧光标记物。

应用

适于用作激光染料

象形图

Exclamation mark

警示用语:

Warning

危险声明

危险分类

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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J R Tchoupe et al.
Biochimica et biophysica acta, 1076(1), 149-151 (1991-01-08)
N-trifluoromethylcoumarinylamide derivatives of benzyloxycarbonyl-Arg-Arg, benzyloxycarbonyl-Phe-Arg and Arg are convenient chromogenic and fluorogenic substrates of cathepsin B, L and H, respectively. Benzyloxycarbonyl-Phe-Arg-N-trifluoromethylcoumarinylamide is also a highly sensitive substrate for papain.
Zhimin Tao et al.
Molecular pharmaceutics, 4(4), 583-595 (2007-04-19)
This study measures the time-dependence of cellular caspase activation by anticancer drugs and compares it with that of cellular respiration. Intracellular caspase activation and cellular respiration were measured during continuous exposure of Jurkat, HL-60, and HL-60/MX2 (deficient in topoisomerase-II) cells
S Reichardt et al.
Science (New York, N.Y.), 367(6485), 1482-1485 (2020-03-29)
The premature abscission of flowers and fruits limits crop yield under environmental stress. Drought-induced flower drop in tomato plants was found to be regulated by phytosulfokine (PSK), a peptide hormone previously known for its growth-promoting and immune-modulating activities. PSK formation
S W Cox et al.
Journal of periodontal research, 24(6), 353-361 (1989-11-01)
Crevicular fluid samples were collected from 20 gingivitis and periodontitis patients using filter paper strips; these were then eluted into buffer. Portions of each sample were combined and the activities of this pooled eluate against different peptidyl derivatives of 7-amino-4-trifluoromethyl
Heike Helmbach et al.
The Journal of investigative dermatology, 118(6), 923-932 (2002-06-13)
Anticancer drugs kill susceptible cells through induction of apoptosis. Alterations of apoptotic pathways in drug-resistant tumor cells leading to apoptosis deficiency might represent a potent mechanism conferring drug resistance. We have assessed the effect of etoposide and cisplatin on the

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