所有图片(3)
别名:
香豆素 151
经验公式（希尔记法）:
C10H6F3NO2
CAS号:
分子量:
229.16
Beilstein:
4456797
EC 号:
MDL编号:
UNSPSC代码:
12171500
PubChem化学物质编号:
NACRES:
NA.47
推荐产品
质量水平
检测方案
≥99%
形式
(Powder or Crystals or Chunks)
mp
221-222 °C (lit.)
λmax
≤207 nm
应用
diagnostic assay manufacturing
hematology
histology
储存温度
room temp
SMILES字符串
Nc1ccc2c(OC(=O)C=C2C(F)(F)F)c1
InChI
1S/C10H6F3NO2/c11-10(12,13)7-4-9(15)16-8-3-5(14)1-2-6(7)8/h1-4H,14H2
InChI key
JBNOVHJXQSHGRL-UHFFFAOYSA-N
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一般描述
7-氨基-4-（三氟甲基）香豆素（AFC）是用于检测蛋白酶的一种新型荧光标记物。
应用
适于用作激光染料
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
Zhimin Tao et al.
Molecular pharmaceutics, 4(4), 583-595 (2007-04-19)
This study measures the time-dependence of cellular caspase activation by anticancer drugs and compares it with that of cellular respiration. Intracellular caspase activation and cellular respiration were measured during continuous exposure of Jurkat, HL-60, and HL-60/MX2 (deficient in topoisomerase-II) cells
S W Cox et al.
Archives of oral biology, 32(9), 599-605 (1987-01-01)
The cysteine proteinases cathepsins B and L have collagenolytic potential and so have been implicated in connective-tissue breakdown in chronic periodontitis. Synthetic peptide substrates are often used to detect proteolytic enzymes. The action of homogenates of inflamed gingiva tissue against
J R Tchoupe et al.
Biochimica et biophysica acta, 1076(1), 149-151 (1991-01-08)
N-trifluoromethylcoumarinylamide derivatives of benzyloxycarbonyl-Arg-Arg, benzyloxycarbonyl-Phe-Arg and Arg are convenient chromogenic and fluorogenic substrates of cathepsin B, L and H, respectively. Benzyloxycarbonyl-Phe-Arg-N-trifluoromethylcoumarinylamide is also a highly sensitive substrate for papain.
Heike Helmbach et al.
The Journal of investigative dermatology, 118(6), 923-932 (2002-06-13)
Anticancer drugs kill susceptible cells through induction of apoptosis. Alterations of apoptotic pathways in drug-resistant tumor cells leading to apoptosis deficiency might represent a potent mechanism conferring drug resistance. We have assessed the effect of etoposide and cisplatin on the
Takayasu Kawasaki et al.
Bioscience, biotechnology, and biochemistry, 76(4), 762-766 (2012-04-10)
Aggregations of proteins are in many cases associated with neurodegenerative diseases such as Alzheimer's (AD). Small compounds capable of inhibiting protein aggregation are expected to be useful for not only in the treatment of disease but also in probing the
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