328820
4-氟苯基溴化镁 溶液
1.0 M in THF
别名:
p-Fluorophenylmagnesium bromide, Bromo(4-fluorophenyl)magnesium, Bromo(p-fluorophenyl)magnesium
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关于此项目
线性分子式:
FC6H4MgBr
化学文摘社编号:
分子量:
199.30
UNSPSC Code:
12352103
NACRES:
NA.22
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
636802
InChI
1S/C6H4F.BrH.Mg/c7-6-4-2-1-3-5-6;;/h2-5H;1H;/q;;+1/p-1
SMILES string
Fc1ccc([Mg]Br)cc1
InChI key
QYBFFRXNNFXREA-UHFFFAOYSA-M
reaction suitability
reaction type: Grignard Reaction
concentration
1.0 M in THF
density
1.021 g/mL at 25 °C
functional group
fluoro
Quality Level
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Application
4-氟苯基溴化镁溶液（格氏试剂）可用作合成以下化合物的试剂：
- 帕罗西汀合成中的关键中间体。
- 通过与硫醇的交叉偶联反应生成芳基硫化物。
- 作为雄激素受体拮抗剂的4-芳基甲基-1-苯基吡唑和4-芳氧基-1-苯基吡唑衍生物。
- 用于制备阿瑞吡坦的Grignard 中间体。
signalword
Danger
Hazard Classifications
Acute Tox. 4 Oral - Carc. 2 - Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1B - STOT SE 3
target_organs
Respiratory system
supp_hazards
存储类别
3 - Flammable liquids
wgk
WGK 3
flash_point_f
-4.0 °F - closed cup
flash_point_c
-20 °C - closed cup
ppe
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
法规信息
危险化学品
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