328820
4-氟苯基溴化镁 溶液
1.0 M in THF
别名:
p-Fluorophenylmagnesium bromide, Bromo(4-fluorophenyl)magnesium, Bromo(p-fluorophenyl)magnesium
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关于此项目
线性分子式:
FC6H4MgBr
化学文摘社编号:
分子量:
199.30
Beilstein:
636802
MDL编号:
UNSPSC代码:
12352103
PubChem化学物质编号:
NACRES:
NA.22
质量水平
反应适用性
reaction type: Grignard Reaction
浓度
1.0 M in THF
密度
1.021 g/mL at 25 °C
官能团
fluoro
SMILES字符串
Fc1ccc([Mg]Br)cc1
InChI
1S/C6H4F.BrH.Mg/c7-6-4-2-1-3-5-6;;/h2-5H;1H;/q;;+1/p-1
InChI key
QYBFFRXNNFXREA-UHFFFAOYSA-M
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应用
4-氟苯基溴化镁溶液（格氏试剂）可用作合成以下化合物的试剂：
- 帕罗西汀合成中的关键中间体。
- 通过与硫醇的交叉偶联反应生成芳基硫化物。
- 作为雄激素受体拮抗剂的4-芳基甲基-1-苯基吡唑和4-芳氧基-1-苯基吡唑衍生物。
- 用于制备阿瑞吡坦的Grignard 中间体。
警示用语：
Danger
危险分类
Acute Tox. 4 Oral - Carc. 2 - Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1B - STOT SE 3
靶器官
Respiratory system
补充剂危害
储存分类代码
3 - Flammable liquids
WGK
WGK 3
闪点(°F)
-4.0 °F - closed cup
闪点(°C)
-20 °C - closed cup
个人防护装备
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
法规信息
危险化学品
此项目有
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