359688
Boc-Lys-OH
99%
别名:
Nα-(叔丁氧羰基)-L-赖氨酸, Nα-Boc-L-赖氨酸
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关于此项目
线性分子式:
NH2(CH2)4CH(COOH)NHCOOC(CH3)3
CAS Number:
分子量:
246.30
Beilstein:
4252546
MDL编号:
UNSPSC代码:
12352209
eCl@ss:
32160406
PubChem化学物质编号:
NACRES:
NA.22
质量水平
方案
99%
表单
solid
旋光性
[α]/D 4.1 to 5.1°, c = 2 in water
反应适用性
reaction type: Boc solid-phase peptide synthesis
mp
~205 °C (dec.) (lit.)
应用
peptide synthesis
SMILES字符串
CC(C)(C)OC(=O)N[C@@H](CCCCN)C(O)=O
InChI
1S/C11H22N2O4/c1-11(2,3)17-10(16)13-8(9(14)15)6-4-5-7-12/h8H,4-7,12H2,1-3H3,(H,13,16)(H,14,15)/t8-/m0/s1
InChI key
DQUHYEDEGRNAFO-QMMMGPOBSA-N
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应用
Boc-Lys-OH(Nα-叔丁氧羰基-L-赖氨酸)可作为构建单元用于合成:
- 作为生物标记试剂,应用于基于异三功能肽的连接体分子。
- 合成氮杂环和蒽醌的赖氨酸衍生物。
- Boc-Lys(Bn4-DTPA)-OH,作为前体合成含肽的二乙基三胺五乙酸(DTPA)。
- 二茂铁-氨基酸共轭物,用于开发化学战剂(CWA)传感器。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Synthesis of lysine derivatives containing aza-crown ethers and a chromophore unit
Ossowski T, et al.
Tetrahedron Letters, 46(10), 1735-1738 (2005)
A novel heterotrifunctional peptide-based cross-linking reagent for facile access to bioconjugates. Applications to peptide fluorescent labelling and immobilisation
Clave G, et al.
Organic & Biomolecular Chemistry, 6(17), 3065-3078 (2008)
Synthesis of Nα-Boc-Nε-tetrabenzyl-DTPA-l-lysine and Nα-Fmoc-Nε-tetra-t-butyl-DTPA-l-lysine, building blocks for solid phase synthesis of DTPA-containing peptides
Davies JS and Al-Jamri L
Journal of Peptide Science, 8(12), 663-670 (2002)
Carla Kühn et al.
Molecular nutrition & food research, 62(20), e1800588-e1800588 (2018-08-10)
Different metabolic and excretion pathways of the benzyl glucosinolate breakdown products benzyl isothiocyanate and benzyl cyanide are investigated to obtain information about their multiple fate after ingestion. Detailed focus is on the so far underestimated transformation/excretion pathways-protein conjugation and exhalation.
Carla Kühn et al.
Journal of agricultural and food chemistry, 66(26), 6727-6733 (2018-06-09)
Glucosinolates and their breakdown products, especially isothiocyanates (ITCs), are hypothesized to exert a broad range of bioactivities. However, physiological mechanisms are not yet completely understood. In this study, formation of protein conjugates after incubation with benzyl isothiocyanate (BITC) was investigated
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