37347
O-(2-氧代-1(2H)吡啶基)-N,N,N′,N′-四甲基脲四氟硼酸盐
≥99.0% (HPLC)
别名:
O-(1,2-二氢-2-氧代-1-吡啶基)-N,N,N′-N′-四甲基脲四氟硼酸盐, TPTU
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关于此项目
经验公式（希尔记法）:
C10H16BF4N3O2
化学文摘社编号:
分子量:
297.06
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352005
MDL number:
产品名称
O-(2-氧代-1(2H)吡啶基)-N,N,N′,N′-四甲基脲四氟硼酸盐, ≥99.0% (HPLC)
InChI key
CZQGINAUZYECAI-UHFFFAOYSA-N
SMILES string
F[B-](F)(F)F.CN(C)C(\ON1C=CC=CC1=O)=[N+](/C)C
InChI
1S/C10H16N3O2.BF4/c1-11(2)10(12(3)4)15-13-8-6-5-7-9(13)14;2-1(3,4)5/h5-8H,1-4H3;/q+1;-1
assay
≥99.0% (HPLC)
reaction suitability
reaction type: Coupling Reactions
mp
140 °C (dec.) (lit.)
application(s)
peptide synthesis
functional group
amine
storage temp.
2-8°C
Quality Level
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Other Notes
多肽合成的偶联剂，特别适合于无外消旋作用的片段缩合反应
Application
Reagent for:
Amidation
Peptide Coupling
Esterification of nucleosides to solid phase supports for oligonucleoside synthesis
Amidation
Peptide Coupling
Esterification of nucleosides to solid phase supports for oligonucleoside synthesis
signalword
Danger
hcodes
Hazard Classifications
Eye Dam. 1 - Skin Sens. 1A
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
C M Huntley et al.
Nucleosides, nucleotides & nucleic acids, 20(4-7), 731-733 (2001-09-21)
The synthesis of 1-(beta-D-ribofuranosyl)pyridin-2-one-3-carboxylic acid and the 3-carboxamide as well as a short series of 3N-carboxamides, prepared by TPTU/HOBt coupling of primary amines with 1-(beta-D-ribofuranosyl)pyridin-2-one-3-carboxylic acid, and their evaluation as anti-infective agents is described.
R T Pon et al.
Bioconjugate chemistry, 10(6), 1051-1057 (1999-11-24)
Nucleosides can be esterified to solid-phase supports using uronium or phosphonium coupling reagents and a coupling additive, such as 1-hydroxybenzotriazole (HOBT), 7-aza-1-hydroxybenzotriazole (HOAT), N-methylimidazole (NMI), or 4-(dimethylamino)pyridine (DMAP). However, DMAP was far superior to other additives and high nucleoside loadings
Tomohisa Sawada et al.
Journal of the American Chemical Society, 133(19), 7336-7339 (2011-04-28)
Artificial mimicry of α-helices offers a basis for development of protein-protein interaction antagonists. Here we report a new type of unnatural peptidic backbone, containing α-, β-, and γ-amino acid residues in an αγααβα repeat pattern, for this purpose. This unnatural
Knorr, R, et al.
Tetrahedron Letters, 30, 1927-1927 (1989)
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