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Merck
CN

392731

(DHQD)2PHAL

greener alternative

≥95%

别名:

氢化奎尼定 1,4-(2,3-二氮杂萘)二醚

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关于此项目

经验公式（希尔记法）:
C48H54N6O4
化学文摘社编号:
140853-10-7
分子量:
778.98
UNSPSC Code:
12352005
NACRES:
NA.22
PubChem Substance ID:
24864481
MDL number:
MFCD00198107
Beilstein/REAXYS Number:
5475678

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产品名称

(DHQD)2PHAL, ≥95%

InChI

1S/C48H54N6O4/c1-5-29-27-53-21-17-31(29)23-43(53)45(35-15-19-49-41-13-11-33(55-3)25-39(35)41)57-47-37-9-7-8-10-38(37)48(52-51-47)58-46(44-24-32-18-22-54(44)28-30(32)6-2)36-16-20-50-42-14-12-34(56-4)26-40(36)42/h7-16,19-20,25-26,29-32,43-46H,5-6,17-18,21-24,27-28H2,1-4H3/t29-,30-,31-,32-,43+,44+,45-,46-/m0/s1

SMILES string

CC[C@H]1CN2CCC1CC2[C@@H](Oc3nnc(O[C@H](C4CC5CCN4C[C@@H]5CC)c6ccnc7ccc(OC)cc67)c8ccccc38)c9ccnc%10ccc(OC)cc9%10

InChI key

YUCBLVFHJWOYDN-HVLQGHBFSA-N

assay

≥95%

form

powder

optical activity

[α]22/D −262°, c = 1.2 in methanol

greener alternative product score

old score: 5
new score: 3
Find out more about DOZN™ Scoring

greener alternative product characteristics

Waste Prevention
Less Hazardous Chemical Syntheses
Safer Solvents and Auxiliaries
Inherently Safer Chemistry for Accident Prevention
Learn more about the Principles of Green Chemistry.

sustainability

Greener Alternative Product

mp

160 °C (dec.) (lit.)

greener alternative category

, Re-engineered

Quality Level

200

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Legal Information

经 Rhodia Pharma Solutions 授权销售。

Application

(DHQD)2PHAL may be used as ligand for:
  • Osmium trioxide catalyzed asymmetric dihydroxylation of olefins.
  • Palladium catalyzed Suzuki-Miyaura coupling of aryl/heteroaryl halides with aryl boronic acids in aqueous medium and in the absence of phosphine/organic solvent.
  • Copper(I)-catalyzed azide-alkyne cycloaddition reaction to synthesize 1,2,3-triazoles in water.
Hydroquinidine 1,4-phthalazinediyl diether [(DHQD)2PHAL] can be used:
  • As a ligand for Sharpless asymmetric dihydroxylation.
  • For enantioselective α-fluorination of carbonyl compounds.

General description

(DHQD)2PHAL is a dimer that can be used as a chiral amine catalyst for asymmetric halogenations.

(DHQD)2PHAL is a modified cinchona alkaloid derivative mainly used as a ligand for enantioselective catalysis.
We are committed to bringing you Greener Alternative Products, which adhere to one of the four categories of Greener Alternatives . This product belongs to category of Re-engineered products, showing key improvements in Green Chemistry Principles “Waste Prevention”, “Less Hazardous Chemical Syntheses”, "Safer Solvents and Auxiliaries" and “Inherently Safer Chemistry for Accident Prevention”. Click here to view its DOZN scorecard.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

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分析证书(COA)

Lot/Batch Number
0000257139
0000215490
0000257139
0000215490
0000208742

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Syntheses and crystal structures of the cinchona alkaloid derivatives used as ligands in the osmium-catalyzed asymmetric dihydroxylation of olefins.
Amberg W, et al.
The Journal of Organic Chemistry, 58(4), 844-849 (1993)
Pd (OAc) 2 and (DHQD) 2 PHAL as a simple, efficient and recyclable/reusable catalyst system for Suzuki-Miyaura cross-coupling reactions in H 2 O at room temperature.
Saikia B, et al.
New. J. Chem., 39(4), 2440-2443 (2015)
(DHQD) 2 PHAL ligand-accelerated Cu-catalyzed azide-alkyne cycloaddition reactions in water at room temperature.
Ali AA, et al.
Royal Society of Chemistry Advances, 4(110), 64388-64392 (2014)
Chemical Fixation of Carbon Dioxide Co-Catalyzed by a Combination of Schiff Bases or Phenols and Organic Bases.
Shen YM, et al.
European Journal of Organic Chemistry, 2004(14), 3080-3089 (2004)
Synthesis of enantiomerically enriched Baylis--Hillman alcohols from their acetates: combination of kinetic resolution during the salt formation with (DHQD) 2PHAL and following asymmetric induction during hydrolysis with NaHCO3 as a water surrogate
Kim J, et al.
Tetrahedron Letters, 43, 9141-9146 (2002)
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