530174
3-氯-2-氟苯胺
97%
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关于此项目
线性分子式:
ClC6H3(F)NH2
化学文摘社编号:
分子量:
145.56
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
218-283-6
MDL number:
Assay:
97%
InChI key
XWBTZHDDWRNOQH-UHFFFAOYSA-N
InChI
1S/C6H5ClFN/c7-4-2-1-3-5(9)6(4)8/h1-3H,9H2
SMILES string
Nc1cccc(Cl)c1F
assay
97%
refractive index
n20/D 1.564 (lit.)
bp
214 °C (lit.)
density
1.324 g/mL at 25 °C (lit.)
functional group
chloro, fluoro
Quality Level
General description
3-氯-2-氟苯胺是一种二卤取代苯胺。沸点(487.15K)蒸发焓为42.561kjoule/mol。
Application
3-氯-2-氟苯胺可用于制备 2-氯-3-氟溴苯和 4-（（3-氯-2-氟苯基）氨基）-7-甲氧基喹唑啉-6-基乙酸酯。
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
230.0 °F - closed cup
flash_point_c
110 °C - closed cup
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
Synthesis of 2-Chloro-3-fluorobromobenzene [J].
Zhao HY and Pan YQ
Chemical World, 11, 010-010 (2011)
Min Wang et al.
Bioorganic & medicinal chemistry letters, 24(18), 4455-4459 (2014-08-26)
The reference standard AZD8931{2-(4-((4-((3-chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)piperidin-1-yl)-N-methylacetamide} (11a) was synthesized from methyl 4,5-dimethoxy-2-nitrobenzoate or ethyl 4,5-dimethoxy-2-nitrobenzoate and 2-chloro-N-methylacetamide in 11 steps with 2-5% overall chemical yield. The precursor N-desmethyl-AZD8931{2-(4-((4-((3-chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)piperidin-1-yl)acetamide} (11b) was synthesized from methyl 4,5-dimethoxy-2-nitrobenzoate or ethyl 4,5-dimethoxy-2-nitrobenzoate and 2-bromoacetamide in 11 steps
Yaws CL.
Thermophysical Properties of Chemicals and Hydrocarbons, 522-522 (2014)
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