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913839

2-Methylnicotinic acid imidazolide

Name: 2-Methylnicotinic acid imidazolide
Brand: ALDRICH

别名:

(1H-imidazol-1-yl)(2-methylpyridin-3-yl)methanone, 1H-Imidazol-1-yl(2-methyl-3-pyridinyl)methanone, 3-(1H-imidazole-1-carbonyl)-2-methylpyridine, NAI, RNA SHAPE probe, RNA structure probe, mNAI

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关于此项目

经验公式（希尔记法）:

C₁₀H₉N₃O

化学文摘社编号:

1055970-47-2

分子量:

187.20

UNSPSC Code:

12352106

NACRES:

NA.22

MDL number:

MFCD25954959

Form:

powder

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属性

form

powder

Quality Level

100

mp

68-72 °C

storage temp.

2-8°C

SMILES string

[n]2(cncc2)C(=O)c1c(nccc1)C

InChI

1S/C10H9N3O/c1-8-9(3-2-4-12-8)10(14)13-6-5-11-7-13/h2-7H,1H3

InChI key

OWQPEDNXDCVXJO-UHFFFAOYSA-N

说明

Application

2-Methylnicotinic acid imidazolide (NAI or mNAI) is an RNA SHAPE probe for live-cell RNA structure profiling. SHAPE -- or selective 2′-hydroxyl acylation analyzed by primer extension -- uses small, electrophilic chemical probes to react with the 2′-hydroxyl group and provides insight to RNA structure and its dynamics in varied cells states or in cells with gene knockouts. It has also been extended to the SHALiPE approach, selective 2′-hydroxyl acylation with lithium ion-based primer extension.

Other Notes

Conditional control of RNA-guided nucleic acid cleavage and gene editing

Guidelines for SHAPE Reagent Choice and Detection Strategy for RNA Structure Probing Studies

SnapShot: RNA Structure Probing Technologies

Structural Analysis using SHALiPE to Reveal RNA G-Quadruplex Formation in Human Precursor MicroRNA

Determination of in vivo RNA structure in low-abundance transcripts

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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RNA SHAPE analysis in living cells.

Robert C Spitale et al.

Nature chemical biology, 9(1), 18-20 (2012-11-28)

RNA structure has important roles in practically every facet of gene regulation, but the paucity of in vivo structural probes limits current understanding. Here we design, synthesize and demonstrate two new chemical probes that enable selective 2'-hydroxyl acylation analyzed by

Conditional control of RNA-guided nucleic acid cleavage and gene editing.

Shao-Ru Wang et al.

Nature communications, 11(1), 91-91 (2020-01-05)

Prokaryotes use repetitive genomic elements termed CRISPR (clustered regularly interspaced short palindromic repeats) to destroy invading genetic molecules. Although CRISPR systems have been widely used in DNA and RNA technology, certain adverse effects do occur. For example, constitutively active CRISPR

全球贸易项目编号

货号	GTIN
913839-50MG	04061842050765
913839-500MG	04061842050758