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930571

Pomalidomide-piperidine-carboxylic acid

≥95%

greener alternative

更环保的选择

别名:

1-[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl], 1-[2-(2,6-Dioxo-3-piperidyl)-1,3-dioxo-isoindolin-5-yl]piperidine-4-carboxylic acid, 4-Piperidinecarboxylic acid

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关于此项目

经验公式(希尔记法):
C19H19N3O6
化学文摘社编号:
分子量:
385.37
UNSPSC Code:
12352100
NACRES:
NA.21
MDL number:
Assay:
≥95%
Form:
powder
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ligand

pomalidomide

Quality Segment

assay

≥95%

form

powder

greener alternative product score

old score: 59
new score: 43
Find out more about DOZN™ Scoring

greener alternative product characteristics

Safer Solvents and Auxiliaries
Design for Energy Efficiency
Design for Degradation
Learn more about the Principles of Green Chemistry.

sustainability

Greener Alternative Product

functional group

carboxylic acid

greener alternative category

storage temp.

2-8°C

SMILES string

O=C(O)C1CCN(C2=CC=C3C(=O)N(C(=O)C3=C2)C4C(=O)NC(=O)CC4)CC1

InChI

1S/C19H19N3O6/c23-15-4-3-14(16(24)20-15)22-17(25)12-2-1-11(9-13(12)18(22)26)21-7-5-10(6-8-21)19(27)28/h1-2,9-10,14H,3-8H2,(H,27,28)(H,20,23,24)

InChI key

LXOQUSNJOGMSJJ-UHFFFAOYSA-N

General description

We are committed to bringing you Greener Alternative Products, which adhere to one of the four categories of Greener Alternatives . This product belongs to category of Re-engineered products, showing key improvements in Green Chemistry Principles “Safer Solvents and Auxiliaries”, “Design for Energy Efficiency”, and “Design for Degradation”. Click here to view its DOZN scorecard.

Application

Pomalidomide-piperidine-carboxylic acid is a functionalized cereblon ligand for development of pomalidomide-based PROTACs. Allows rapid conjugation with amine linkers due to the presence of a carboxyl group via peptide coupling reactions. A basic building block for development of a protein degrader library.

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Protein Degrader Building Blocks


pictograms

Health hazard

signalword

Danger

hcodes

Hazard Classifications

Repr. 1B

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3



历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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