Pomalidomide-piperidine-carboxylic acid

Name: Pomalidomide-piperidine-carboxylic acid
Brand: ALDRICH

≥95%

别名:

1-[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl], 1-[2-(2,6-Dioxo-3-piperidyl)-1,3-dioxo-isoindolin-5-yl]piperidine-4-carboxylic acid, 4-Piperidinecarboxylic acid

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所有图片(1)

About This Item

经验公式（希尔记法）:

C₁₉H₁₉N₃O₆

CAS Number:

2467965-70-2

分子量:

385.37

MDL编号:

MFCD34570925

UNSPSC代码:

12352100

NACRES:

NA.21

ligand

pomalidomide

质量水平

100

方案

≥95%

表单

powder

环保替代产品得分

old score: 59
new score: 43
Find out more about DOZN™ Scoring

环保替代产品特性

Safer Solvents and Auxiliaries
Design for Energy Efficiency
Design for Degradation
Learn more about the Principles of Green Chemistry.

sustainability

Greener Alternative Product

官能团

carboxylic acid

环保替代产品分类

Re-engineered

储存温度

2-8°C

SMILES字符串

O=C(O)C1CCN(C2=CC=C3C(=O)N(C(=O)C3=C2)C4C(=O)NC(=O)CC4)CC1

InChI

1S/C19H19N3O6/c23-15-4-3-14(16(24)20-15)22-17(25)12-2-1-11(9-13(12)18(22)26)21-7-5-10(6-8-21)19(27)28/h1-2,9-10,14H,3-8H2,(H,27,28)(H,20,23,24)

InChI key

LXOQUSNJOGMSJJ-UHFFFAOYSA-N

一般描述

We are committed to bringing you Greener Alternative Products, which adhere to one of the four categories of Greener Alternatives . This product belongs to category of Re-engineered products, showing key improvements in Green Chemistry Principles “Safer Solvents and Auxiliaries”, “Design for Energy Efficiency”, and “Design for Degradation”. Click here to view its DOZN scorecard.

应用

Pomalidomide-piperidine-carboxylic acid is a functionalized cereblon ligand for development of pomalidomide-based PROTACs. Allows rapid conjugation with amine linkers due to the presence of a carboxyl group via peptide coupling reactions. A basic building block for development of a protein degrader library.

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