description
Application - Tissue engineering, Application - cell culture, Bioburden (Total Aerobic): <5 CFU/ml, Bioburden (fungal): < 5 CFU/mL, Endotoxin: <50 EU/ml
composition
PODS Human BMP-2, 25 µg , PODS Human BMP-4, 25 µg , PODS Human IGF-1, 25 µg , PODS Human RANK Ligand, 25 µg , TissueFab® bone bioink, Vis/405 nm
color
white
viscosity
5-50 cP
compatibility
(extrusion-based 3D bioprinting)
storage temp.
−20°C
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General description
Rethink your bioinks with TissueFab®
About the material:
The TissueFab PODS Growth Factor Loaded Bioink Kit, Bone differentiation, Vis/405 nm contains:
Printing and crosslinking parameters:
TissueFab POD Growth Factor Loaded Bioink kit, Bone differentiation, Vis/405 nm, low endotoxin is a ready-to-use bioink kit which is formulated for high cell viability, printing fidelity, and is designed for extrusion-based 3D bioprinting and subsequent crosslinking with exposure to 405nm visible light. TissueFab POD Growth Factor Loaded Bioink kit, Bone differentiation, Vis/405 nm, low endotoxin can be used with most extrusion-based bioprinters, is biodegradable, and is compatible with human mesenchymal stem cells (hMSCs).
TissueFab bioink Bone Vis/405 nm, low endotoxin is designed for promoting osteogenic differentiation of stem cells. It is based on Gelatin methacryloyl (GelMA) - Hydroxyapatite (HAp) hydrogel system.
HAp is a highly crystalline form of calcium phosphate. HAp has a chemical similarity with the mineralized phase of bone which accounts for their excellent biocompatibility and osteoinductive and osteoconductive properties favorable for bone regeneration. HAp-containing hydrogels has been studied in literature to demonstrate their processability with different additive manufacturing approaches. Printing of cell laden structures with HAp containing bioink formulations have shown superior osteogenic properties.
Included growth facors, BMP-2, BMP-4, IGF-1, and RANK ligand, are known to play crucial roles in osteogenic differentiation. Their inclusion with PODS® delivery system allows their sustained release within bioprinted constructs and retainment of 70% bioactivity after 6 months. When mixed with the bioink component, the included PODS growth factors can promote bone differentiation of encapsulated cells.
More information and a step by step protocol can be found under the "More Documents" section of this page.
About the material:
The TissueFab PODS Growth Factor Loaded Bioink Kit, Bone differentiation, Vis/405 nm contains:
- Low endotoxin GelMA-based bioink containing a visible light photoinitiator and hydroxyapatite
- Human BMP-2 PODS
- Human BMP-4 PODS
- Human IGF-1 PODS
- Human RANK Ligand PODS
Printing and crosslinking parameters:
- Suitable for extrusion-based bioprinting
- Photoinitiator-assisted crosslinking at 405nm wavelength (Visible light)
TissueFab POD Growth Factor Loaded Bioink kit, Bone differentiation, Vis/405 nm, low endotoxin is a ready-to-use bioink kit which is formulated for high cell viability, printing fidelity, and is designed for extrusion-based 3D bioprinting and subsequent crosslinking with exposure to 405nm visible light. TissueFab POD Growth Factor Loaded Bioink kit, Bone differentiation, Vis/405 nm, low endotoxin can be used with most extrusion-based bioprinters, is biodegradable, and is compatible with human mesenchymal stem cells (hMSCs).
TissueFab bioink Bone Vis/405 nm, low endotoxin is designed for promoting osteogenic differentiation of stem cells. It is based on Gelatin methacryloyl (GelMA) - Hydroxyapatite (HAp) hydrogel system.
HAp is a highly crystalline form of calcium phosphate. HAp has a chemical similarity with the mineralized phase of bone which accounts for their excellent biocompatibility and osteoinductive and osteoconductive properties favorable for bone regeneration. HAp-containing hydrogels has been studied in literature to demonstrate their processability with different additive manufacturing approaches. Printing of cell laden structures with HAp containing bioink formulations have shown superior osteogenic properties.
Included growth facors, BMP-2, BMP-4, IGF-1, and RANK ligand, are known to play crucial roles in osteogenic differentiation. Their inclusion with PODS® delivery system allows their sustained release within bioprinted constructs and retainment of 70% bioactivity after 6 months. When mixed with the bioink component, the included PODS growth factors can promote bone differentiation of encapsulated cells.
More information and a step by step protocol can be found under the "More Documents" section of this page.
Application
TissueFab® POD Growth Factor Loaded Bioink kit, Bone differentiation, Vis/405 nm, low endotoxin enables the precise fabrication of osteogenic 3D cell models and tissue constructs for research in 3D cell biology, tissue engineering, in vitro tissue models, and regenerative medicine.
Features and Benefits
Key Features and Benefits:
Each TissueFab® bioink is developed and tested to meet strict criteria to best suit researchers′ needs. This includes:
Each TissueFab® bioink is developed and tested to meet strict criteria to best suit researchers′ needs. This includes:
- Printability and rheological properties
- Crosslinking
- Cell viability
- Biocompatibility
- Low bioburden
- Low endotoxin
Legal Information
PODS is a registered trademark of Cell Guidance Systems Ltd
TISSUEFAB is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
10 - Combustible liquids
wgk
WGK 3
法规信息
新产品
此项目有
Hantao Cai et al.
Molecular medicine reports, 23(2) (2020-12-11)
With increasing age, the microenvironment in the bone marrow is altered, leading to a decrease in bone marrow mesenchymal stem cell (BMSC) differentiation, which reduces the number of bone cells and weakens osteogenic capacity, resulting in osteoporosis (OP). The clinical
Maolin Zhang et al.
Stem cells international, 2018, 3272098-3272098 (2018-12-06)
Regenerative medicine for bone tissue mainly depends on efficient recruitment of endogenous or transplanted stem cells to guide bone regeneration. Platelet-derived growth factor (PDGF) is a functional factor that has been widely used in tissue regeneration and repair. However, the
Jing Feng et al.
Experimental and therapeutic medicine, 22(2), 891-891 (2021-07-02)
Bone marrow mesenchymal stem cells (BMSCs) are stem cells that exist in bone marrow tissue and have osteogenic differentiation potential. Insulin growth factor-1 (IGF-1) plays a key role in the proliferation and osteogenic differentiation of BMSCs. However, the specific mechanism
Xiao-Yun Huang et al.
International journal of biological macromolecules, 265(Pt 1), 130649-130649 (2024-03-08)
Bone Morphogenetic Protein 4 (BMP4) is crucial for bone and cartilage tissue regeneration, essential in medical tissue engineering, cosmetology, and aerospace. However, its cost and degradation susceptibility pose significant clinical challenges. To enhance its osteogenic activity while reducing dosage and
Silke Wüst et al.
Acta biomaterialia, 10(2), 630-640 (2013-10-26)
Three-dimensional (3-D) bioprinting is the layer-by-layer deposition of biological material with the aim of achieving stable 3-D constructs for application in tissue engineering. It is a powerful tool for the spatially directed placement of multiple materials and/or cells within the
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