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关于此项目
经验公式（希尔记法）:
C53H93N2O15Ni
化学文摘社编号:
分子量:
1057.00
MDL number:
NACRES:
NA.25
UNSPSC Code:
12352211
description
1,2-dioleoyl-sn-glycero-3-[(N-(5-amino-1-carboxypentyl)iminodiacetic acid)succinyl] (nickel salt)
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 10 mg (790404P-10mg), pkg of 1 × 25 mg (790404P-25mg), pkg of 1 × 5 mg (790404P-5mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand
shipped in
dry ice
storage temp.
−20°C
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General description
1,2-二油酰基-sn-甘油基-3-[（N-（5-氨基-1-羧基戊基）亚氨基二乙酸）琥珀酰基]氮川三乙酸（NTA）（18：1 DGS-NTA（Ni））是含镍的共轭磷脂 。NTA与镍离子中存在六个配位点中的四个螯合。
Application
1,2-二油酰基-sn-甘油基-3-[（N-（5-氨基-1-羧基戊基）亚氨基二乙酸）琥珀酰基]（镍盐）（18：1 DGS-NTA（Ni））用于：
- 制备含卟啉-磷脂（PoP）偶联物的脂质体，用于蛋白质和肽的结合研究
- 制备纳米级多层囊泡（NMV），用于抗原递送研究
- 作为小单层囊泡（SUV）成分，用于制备平面脂质膜（PM）
Biochem/physiol Actions
1,2-二油酰基-sn-甘油基-3-[（N-（5-氨基-1-羧基戊基）亚氨基二乙酸）琥珀酰基]氮川三乙酸（NTA）（18：1 DGS-NTA（Ni））可用于结构生物学，尤其适合重组组氨酸标签结合蛋白。 虽然用处很大，但纳米颗粒在生物样品中存在稳定性问题。因此，NTA-脂质缀合物主要用作脂质体或纳米颗粒涂层。基于DGS-NTA（Ni）的纳米级多层囊泡（NMV）是有效的疫苗递送系统。
Packaging
5 mL透明玻璃密封安瓿（790404P-25mg）
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
No data available
flash_point_c
No data available
Priyanka D Abeyrathne et al.
Methods in enzymology, 481, 25-43 (2010-10-05)
Electron crystallography is a powerful technique for the structure determination of membrane proteins as well as soluble proteins. Sample preparation for 2D membrane protein crystals is a crucial step, as proteins have to be prepared for electron microscopy at close
Thanh X Dang et al.
Journal of structural biology, 152(2), 129-139 (2005-10-26)
To facilitate purification and subsequent structural studies of recombinant proteins the most widely used genetically encoded tag is the histidine tag (His-tag) which specifically binds to N-nitrilotriacetic-acid-chelated nickel ions. Lipids derivatized with a nickel-chelating head group can be mixed with
Decorating liquid crystal surfaces with proteins for real-time detection of specific protein-protein binding
Hartono D, et al.
Advances in Functional Materials, 19(22), 3574-3579 (2009)
John Monsey et al.
The Journal of biological chemistry, 285(10), 7035-7044 (2009-12-22)
Her4 (ErbB-4) and Her2/neu (ErbB-2) are receptor-tyrosine kinases belonging to the epidermal growth factor receptor (EGFR) family. Crystal structures of EGFR and Her4 kinase domains demonstrate kinase dimerization and activation through an allosteric mechanism. The kinase domains form an asymmetric
Elizabeth M Wilson-Kubalek et al.
Methods in enzymology, 481, 45-62 (2010-10-05)
Helical protein arrays offer unique advantages for structure determination by cryo-electron microscopy (cryo-EM). A single image of such an array contains a complete range of equally spaced molecular views of the underlying protein subunits, which allows a low-resolution, isotropic three-dimensional
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