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860586P

Avanti

18:0 SM (d18:1/18:0)

Avanti Polar Lipids 860586P, powder

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别名:
N-硬脂酰-D-赤-鞘氨醇磷酸胆碱
经验公式（希尔记法）:
C41H83N2O6P
CAS号:
58909-84-5
分子量:
731.08
NACRES:
NA.25

形式

powder

包装

pkg of 1 × 10 mg (860586P-10mg)
pkg of 1 × 5 mg (860586P-5mg)

制造商/商品名称

Avanti Polar Lipids 860586P

脂质类型

sphingolipids

运输

dry ice

储存温度

−20°C

SMILES字符串

[H][C@](/C=C/CCCCCCCCCCCCC)(O)[C@@]([H])(NC(CCCCCCCCCCCCCCCCC)=O)COP([O-])(OCC[N+](C)(C)C)=O

InChI

1S/C41H83N2O6P/c1-6-8-10-12-14-16-18-20-21-23-25-27-29-31-33-35-41(45)42-39(38-49-50(46,47)48-37-36-43(3,4)5)40(44)34-32-30-28-26-24-22-19-17-15-13-11-9-7-2/h32,34,39-40,44H,6-31,33,35-38H2,1-5H3,(H-,42,45,46,47)/b34-32+/t39-,40+/m0/s1

InChI key

LKQLRGMMMAHREN-YJFXYUILSA-N

应用

N-硬脂酰-D-赤型-鞘氨醇磷酸胆碱(18:0 SM (d18:1/18:0))已用于：
  • 作为脂质体组分测定ostreolysin A(OlyA)结合，用于研究磷脂酰胆碱(PC)对鞘磷脂(SM)/胆固醇相互作用的影响
  • 作为鞘脂代谢物定量分析的标准品
  • 作为液相色谱-串联质谱(LC/MS/MS)法对表皮脂质进行绝对定量的标准品

包装

5 mL棕色玻璃螺旋盖样品瓶（860586P-10mg）
5 mL棕色玻璃螺旋盖样品瓶（860586P-5mg）

储存分类代码

11 - Combustible Solids

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Xingzhong Zhang et al.
Cell metabolism, 30(5), 937-951 (2019-11-02)
Obesity-induced adipose dysfunction is a major contributor to atherosclerosis. Cold exposure has been reported to affect atherosclerosis through regulation of adipose function, but the mechanism has not been well clarified. Here, adipocyte hypoxia-inducible factor 2α (HIF-2α) was upregulated after mild cold
Shreya Endapally et al.
Cell, 176(5), 1040-1053 (2019-02-05)
Sphingomyelin and cholesterol are essential lipids that are enriched in plasma membranes of animal cells, where they interact to regulate membrane properties and many intracellular signaling processes. Despite intense study, the interaction between these lipids in membranes is not well
Zhixing Wang et al.
The Journal of investigative dermatology, 133(3), 668-676 (2012-10-26)
The stratum corneum is composed of protein-enriched corneocytes embedded in an intercellular matrix of nonpolar lipids organized as lamellar layers and giving rise to epidermal permeability barrier (EPB). EPB defects have an important role in the pathophysiology of skin diseases
Marion Régnier et al.
Scientific reports, 10(1), 6489-6489 (2020-04-18)
Peroxisome proliferator activated receptor α (PPARα) acts as a fatty acid sensor to orchestrate the transcription of genes coding for rate-limiting enzymes required for lipid oxidation in hepatocytes. Mice only lacking Pparα in hepatocytes spontaneously develop steatosis without obesity in
Delphine Milhas et al.
FEBS letters, 584(9), 1887-1894 (2009-10-28)
The plasma membrane (PM) is a major resource for production of bioactive lipids and contains a large proportion of the cellular sphingomyelin (SM) content. Consequently, the regulation of SM levels at the PM by enzymes such as sphingomyelinase (SMase) and
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