产品名称
C16-02:0 DG, Avanti Research™ - A Croda Brand 878118C
方案
>99% (TLC)
表单
liquid
包装
pkg of 1 × 5 mL (878118C-5mg)
制造商/商品名称
Avanti Research™ - A Croda Brand 878118C
浓度
1 mg/mL (878118C-5mg)
运输
dry ice
储存温度
−20°C
SMILES字符串
OC[C@]([H])(OC(C)=O)COCCCCCCCCCCCCCCCC
一般描述
C16-02:0 DG, also known as 1-O-hexadecyl-2-acetyl-sn-glycerol (HAG), is an alkylacylglycerol containing primary alcohol group at the C3 position.
应用
C16-02:0 DG or 1-O-hexadecyl-2-acetyl-sn-glycerol (HAG) may be used to inhibit the formation of 1-O-acyl-NAS.
生化/生理作用
C16-02:0 DG or 1-O-hexadecyl-2-acetyl-sn-glycerol (HAG), is a protein kinase C (PKC) inhibitor and diacylglycerol (DAG) antagonist. It exhibits growth inhibitory activity against human promyelocytic leukemia cell line HL-60. HAG acts as a precursor in the biosynthesis of platelet-activating factor via remodeling and retroconversion de novo pathway.
包装
30 mL Amber Narrow Mouth Glass Bottle with Screw Cap (878118C-5mg)
法律信息
Avanti Research is a trademark of Avanti Polar Lipids, LLC
警示用语：
Danger
危险分类
Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3
靶器官
Central nervous system
储存分类代码
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGK
WGK 3
闪点(°F)
does not flash
闪点(°C)
does not flash
法规信息
新产品
此项目有
M J McNamara et al.
Biochemical and biophysical research communications, 122(2), 824-830 (1984-07-31)
The human promyelocytic leukemia cell line HL-60 can be differentiated to cells resembling either neutrophils or mononuclear phagocytes by a diverse group of stimuli. However, the underlying mechanisms remain unknown. We report that 1-0-hexadecyl-2-acetyl-sn-glycerol inhibits the growth of HL-60 cells
Jin Tao et al.
Cellular signalling, 21(9), 1436-1443 (2009-05-15)
Corticotropin-releasing factor (CRF) receptors have been demonstrated to be widely expressed in the central nervous system and in many peripheral tissues of mammalians. However, it is still unknown whether CRF receptors will function in cerebellar Purkinje neurons. In the present
Akira Abe et al.
Journal of lipid research, 48(10), 2255-2263 (2007-07-14)
A novel lysosomal phospholipase A(2) (LPLA2) with specificity toward phosphatidylethanolamine and phosphatidylcholine was previously purified and cloned. LPLA2 transfers sn-1 or sn-2 acyl groups of phospholipids to the C1 hydroxyl of the short-chain ceramide N-acetylsphingosine (NAS) under acidic conditions. The
W G Brydon et al.
European journal of gastroenterology & hepatology, 8(2), 117-123 (1996-02-01)
To assess the reliability of serum 7 alpha-hydroxy-4-cholesten-3-one (7 alpha-3ox-C) in the differential diagnosis of bile acid induced diarrhoea by comparison with 75selenohomocholyltaurine whole body retention (SeHCAT WBR). One hundred and sixty-four patients with chronic diarrhoea were investigated prospectively in
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