产品名称
C16-02:0 DG, Avanti Research™ - A Croda Brand 878118C
SMILES string
OC[C@]([H])(OC(C)=O)COCCCCCCCCCCCCCCCC
assay
>99% (TLC)
form
liquid
packaging
pkg of 1 × 5 mL (878118C-5mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 878118C
concentration
1 mg/mL (878118C-5mg)
shipped in
dry ice
storage temp.
−20°C
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General description
C16-02:0 DG, also known as 1-O-hexadecyl-2-acetyl-sn-glycerol (HAG), is an alkylacylglycerol containing primary alcohol group at the C3 position.
Application
C16-02:0 DG or 1-O-hexadecyl-2-acetyl-sn-glycerol (HAG) may be used to inhibit the formation of 1-O-acyl-NAS.
Biochem/physiol Actions
C16-02:0 DG or 1-O-hexadecyl-2-acetyl-sn-glycerol (HAG), is a protein kinase C (PKC) inhibitor and diacylglycerol (DAG) antagonist. It exhibits growth inhibitory activity against human promyelocytic leukemia cell line HL-60. HAG acts as a precursor in the biosynthesis of platelet-activating factor via remodeling and retroconversion de novo pathway.
Packaging
30 mL Amber Narrow Mouth Glass Bottle with Screw Cap (878118C-5mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
signalword
Danger
Hazard Classifications
Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3
target_organs
Central nervous system
存储类别
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
wgk
WGK 3
flash_point_f
does not flash
flash_point_c
does not flash
法规信息
新产品
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M J McNamara et al.
Biochemical and biophysical research communications, 122(2), 824-830 (1984-07-31)
The human promyelocytic leukemia cell line HL-60 can be differentiated to cells resembling either neutrophils or mononuclear phagocytes by a diverse group of stimuli. However, the underlying mechanisms remain unknown. We report that 1-0-hexadecyl-2-acetyl-sn-glycerol inhibits the growth of HL-60 cells
Akira Abe et al.
Journal of lipid research, 48(10), 2255-2263 (2007-07-14)
A novel lysosomal phospholipase A(2) (LPLA2) with specificity toward phosphatidylethanolamine and phosphatidylcholine was previously purified and cloned. LPLA2 transfers sn-1 or sn-2 acyl groups of phospholipids to the C1 hydroxyl of the short-chain ceramide N-acetylsphingosine (NAS) under acidic conditions. The
Jin Tao et al.
Cellular signalling, 21(9), 1436-1443 (2009-05-15)
Corticotropin-releasing factor (CRF) receptors have been demonstrated to be widely expressed in the central nervous system and in many peripheral tissues of mammalians. However, it is still unknown whether CRF receptors will function in cerebellar Purkinje neurons. In the present
W G Brydon et al.
European journal of gastroenterology & hepatology, 8(2), 117-123 (1996-02-01)
To assess the reliability of serum 7 alpha-hydroxy-4-cholesten-3-one (7 alpha-3ox-C) in the differential diagnosis of bile acid induced diarrhoea by comparison with 75selenohomocholyltaurine whole body retention (SeHCAT WBR). One hundred and sixty-four patients with chronic diarrhoea were investigated prospectively in
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