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Merck
CN

E-081

依替唑仑标准液 CRM 溶液

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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经验公式(希尔记法):
C17H15ClN4S
化学文摘社编号:
分子量:
342.85
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
MDL number:
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InChI

1S/C17H15ClN4S/c1-3-11-8-13-16(12-6-4-5-7-14(12)18)19-9-15-21-20-10(2)22(15)17(13)23-11/h4-8H,3,9H2,1-2H3

SMILES string

CCC1=CC2=C(S1)N3C(CN=C2C4=CC=CC=C4Cl)=NN=C3C

InChI key

VMZUTJCNQWMAGF-UHFFFAOYSA-N

grade

certified reference material

form

liquid

feature

(Snap-N-Spike®)

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

drug control

Narcotic Licence Schedule B (Switzerland); Pszichotróp anyag / Psychotropic Substance (Hungary), 78/2022. (XII. 28.) BM rendelet, kontrollierte Droge in Deutschland

Quality Level

concentration

1.0 mg/mL in methanol

technique(s)

gas chromatography (GC): suitable, liquid chromatography (LC): suitable

application(s)

clinical testing

format

single component solution

storage temp.

−20°C

General description

经认证的溶液标准,可用于临床毒理学、尿液药物测试或法医分析中的LC/MS或GC/MS苯二氮卓测试方法。依替唑仑,商品名为Etilaam、Etizola或Depas,是一种苯二氮卓类似物,可用于失眠、焦虑或惊恐发作的短期治疗。依替唑仑也被作为化合致幻药销售,在欧洲和美国都有药物滥用的案例。

Biochem/physiol Actions

依替唑仑是一种噻吩并二氮杂卓抗焦虑药,与其他苯二氮卓类药物相比具有较低的依赖性。它与其他苯并二氮杂卓类药物的不同之处在于其分子具有噻吩环而不是苯环。它具有抗惊厥、镇静、抗焦虑、遗忘、催眠和肌肉松弛作用。它是通过作用于苯二氮卓受体而发挥作用的。它被用于治疗失眠、中度抑郁和社交焦虑症,并偶尔用于治疗眼睑痉挛和皮肤病变。

Legal Information

German
Dieses Produkt fällt unter das Betäubungsmittelgesetz (BtMG). Für eine Bestellung dieses Produktes ist eine Erlaubnis nach § 3 BtMG zwingend erforderlich, es sei denn, es greift eine Ausnahme von der Erlaubnispflicht nach § 4 oder § 26 BtMG.

English
This product is subject to the German Narcotics Act. A permit under Section 3 of the German Narcotics Act is mandatory for ordering this product unless an exemption from the permit requirement under Section 4 or Section 26 of the German Narcotics Act applies.
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

target_organs

Eyes

存储类别

3 - Flammable liquids

wgk

WGK 1

flash_point_f

49.5 °F

flash_point_c

9.7 °C

法规信息

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Toshiaki Makino et al.
Biological & pharmaceutical bulletin, 28(2), 280-284 (2005-02-03)
Kamisyoyosan (KSS) and Tokisyakuyakusan (TSS) are widely used herbal formulas in Japanese traditional kampo medicine to relieve the symptoms occurred in climacteric disturbance. Since Japanese physicians frequently prescribe these formulas combined with etizolam, one of benzodiazepine anxiolytics, we evaluated the
Encyclopedia of Psychopharmacology
Ian Stolerman
Springer Science & Business Media, 502-502 (2010)
A Lopedota et al.
Journal of microencapsulation, 24(3), 214-224 (2007-04-25)
The aim of this study was to gain insight into the feasibility of using microparticles (MPs) constituted by the biodegradable poly (DL-lactide-co-glycolide) (PLGA) and a number of cyclodextrins (CDs) as an orally sustained delivery system of the hypnotic agent etizolam
Yutaro Suzuki et al.
Therapeutic drug monitoring, 26(6), 638-642 (2004-12-01)
Administration of fluvoxamine with concomitant benzodiazepines is common in clinical situations. This study investigated the effects of the coadministration of fluvoxamine on plasma concentrations of etizolam and evaluated the effects of various fluvoxamine doses on drug interactions with etizolam. Subjects
Inclusion of thienodiazepines in prescription rate of anxiolytics.
Katsuhiro Toda
Psychiatry and clinical neurosciences, 63(3), 430-430 (2009-07-02)

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