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Merck
CN

07-520

抗-eNOS/NOS III抗体,CT

Upstate®, from rabbit

别名:

Constitutive NOS, Endothelial NOS, Endothelial NOS, Endothelial NOS, endothelial nitric oxide synthase, nitric oxide synthase 3 (endothelial cell)

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关于此项目

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
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产品名称

抗-eNOS/NOS III抗体,CT, Upstate®, from rabbit

biological source

rabbit

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

species reactivity

mouse, pig, guinea pig, rat, canine, human, bovine

manufacturer/tradename

Upstate®

technique(s)

western blot: suitable

isotype

IgG

NCBI accession no.

UniProt accession no.

shipped in

dry ice

target post-translational modification

unmodified

Quality Level

Gene Information

bovine ... Nos3(287024)
dog ... Nos3(403784)
guinea pig ... Nos3(100135577)
human ... NOS3(4846)
mouse ... Nos3(18127)
pig ... Nos3(397557)
rat ... Nos3(24600)

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Analysis Note

对照
血小板,胎盘,肝脏和肾脏。
已通过蛋白质印迹对HUVEC细胞的RIPA裂解液进行了常规评估。

蛋白质印迹分析:
0.5-2 µg/mL该抗体在来自HUVEC细胞的RIPA裂解液中检测到eNOS/NOS III。

Application

抗eNOS/NOS III抗体,CT检测eNOS/NOS III的水平,&经发布 & 验证可用于WB。

Biochem/physiol Actions

可识别eNOS/NOS III,Mr ~135 kDa。
基于序列同源性,预计与小鼠、豚鼠、猪、大鼠和犬发生交叉反应。

General description

135 kDa
内皮型NOS(eNOS),也称为一氧化氮合酶3(NOS3)或组成型NOS(cNOS),是一氧化氮合酶。它在血管中产生NO,并参与调节血管功能。组成型Ca2+依赖性NOS提供NO的基础释放。eNOS与细胞周围的质膜和细胞内高尔基体的膜有关。

Immunogen

与人eNOS/NOS III的氨基酸 1181-1194(C-QERQLRGAVPWAFD)相对应的KLH偶联的合成肽。 免疫序列在小鼠,豚鼠,牛,猪,大鼠和狗中具有10/11相同的氨基酸。

Other Notes

浓度:请参考批次特异性浓缩物的分析证书。

Physical form

形式:纯化
纯化的兔多克隆IgG,溶于含有0.014M磷酸盐缓冲液(pH 7.6)、0.175M NaCl和0.07%叠氮化钠的缓冲液中,然后添加甘油至30%。 在-20°C为液体形式。

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存储类别

10 - Combustible liquids

wgk

WGK 1


分析证书(COA)

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Suzanne D Burke et al.
The Journal of clinical investigation, 126(7), 2561-2574 (2016-06-09)
Preeclampsia is a hypertensive disorder of pregnancy in which patients develop profound sensitivity to vasopressors, such as angiotensin II, and is associated with substantial morbidity for the mother and fetus. Enhanced vasoconstrictor sensitivity and elevations in soluble fms-like tyrosine kinase
Apigenin inhibits the TNF?-induced expression of eNOS and MMP-9 via modulating Akt signalling through oestrogen receptor engagement.
Daniela Palmieri,Patrizia Perego,Domenico Palombo
Molecular and Cellular Biochemistry null
The senescence-accelerated mouse (SAM-P8) as a model for the study of vascular functional alterations during aging.
Llorens, Silvia, et al.
Biogerontology, 8, 663-672 (2007)
TJ0711, a novel vasodilatory ?-blocker, protects SHR rats against hypertension induced renal injury.
Yang, Juan, et al.
American Journal of Translational Research, 5, 279-290 (2013)
BDNF/TrkB content and interaction with gastrin-releasing peptide receptor blockade in colorectal cancer.
Caroline Brunetto de Farias,Denis Broock Rosemberg,Tiago Elias Heinen et al.
Oncology null

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