ligand
(Trimethylammoniumethyl)
质量水平
描述
strong anion exchanger, suspension in 20% ethanol and 150 mM NaCl (40-90 µm)
无菌性
sterile (Caustic Stable)
形式
resin
特殊分析物
MAbs
参数
180 cm/hr flow rate
8 bar max. pressure
基质活性基团
methacrylate
平均粒径
40-90 μm
容量
180 mg binding capacity (BSA/mg of resin)
转变温度
flash point 35 °C (calculated)
密度
1.430 g/cm3 at 20 °C
堆积密度
1000 kg/m3
应用
recombinant protein
分离技术
anion exchange
strong anion exchange
储存温度
2-30°C
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一般描述
特点和优势
- Efficiently capture target protein and remove viruses, DNA, and endotoxins with its tentacle technology resulting in better production yields and high throughput
- Reduce operating costs and resin replacement with enduring durability - allowing for multiple cycles of column regeneration and sanitization
- Compatibility with 2.5 % (v/v) aqueous benzyl alcohol containing 150 mM NaCl storage solution
Due to the titration behavior of Fractogel® EMD TMAE Hicap (M) the ion exchange capacity can be used from pH 2 to 12. The separation of proteins is based on reversible electrostatic interactions between the negatively charged regions of the proteins′ surface and the support. Proteins are retained efficiently on Fractogel® EMD TMAE Hicap (M) when the pH of the buffer is about 1 unit above their isoelectric points (pl).
The strength of the binding depends on the following:
- the buffer system
- pH value of the buffer which determines the surface charge of the protein
- the concentration of the counter ions
- the charge density on the support (protein binding capacity)
包装
- 1.10316.0100: Fractogel® EMD TMAE Hicap (M) Resin 100ml
- 1.10316.0010: Fractogel® EMD TMAE Hicap (M) Resin 10ml
- 1.10316.0500: Fractogel® EMD TMAE Hicap (M) Resin 500ml
- 1.10316.5000: Fractogel® EMD TMAE Hicap (M) Resin 5L
分析说明
Microscopic evaluation: Uniform spherical particles,no agglomerates,no fines
Extractable matter (water): ≤ 0.03 %
Cerium: ≤ 1 µg/g
Pressure drop(column: ID=1.6 cm, L=10 cm at 5 ml/min): ≤ 1 bar
Particle size (d10): 37 - 45 µm
Particle size (d50): 48 - 60 µm
Particle size (d90): 63 - 77 µm
Colony forming units (TAMC + TYMC): ≤ 100 CFU/ml
Endotoxins: ≤ 1.00 EU/ml
Protein binding capacity (bovine serum albumin): 160 - 200 mg/ml
Functional test (b:a): ≤ 0.25
Functional test: Separation of conalbumin and human serum albumin
法律信息
警示用语：
Warning
危险声明
危险分类
Flam. Liq. 3
储存分类代码
3 - Flammable liquids
WGK
WGK 1
闪点(°F)
95.0 °F
闪点(°C)
35 °C
分析证书(COA)
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示例
其它示例：
705578-5MG-PW
PL860-CGA/SHF-1EA
MMYOMAG-74K-13
1000309185
输入内容 1.000309185)
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商品
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A custom-designed cost model is used to explore the economics of vaccine manufacturing across several different modalities including mRNA. The model enables greater process understanding, simulates bottlenecks, and helps to optimize production efficiency.
Learn more one the attenuated viral vaccines manufacturing process: cell culture, clarification, nuclease treatment, chromatography, and sterile filtration.
This technical article breaks down the steps of upstream and downstream bioprocessing and formulation of virus-like particle vaccines.
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