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Merck
CN

8.17043

硫柳汞

EMPROVE® ESSENTIAL, Ph. Eur., BP

别名:

Thimerosal

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经验公式(希尔记法):
C9H9HgNaO2S
化学文摘社编号:
分子量:
404.81
UNSPSC Code:
12352103
EC Index Number:
200-210-4
MDL number:
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产品名称

硫柳汞, EMPROVE® ESSENTIAL, Ph. Eur., BP

SMILES string

[Hg+]CC.[Na+].[S-]c1c(cccc1)C(=O)[O-]

InChI

1S/C7H6O2S.C2H5.Hg.Na/c8-7(9)5-3-1-2-4-6(5)10;1-2;;/h1-4,10H,(H,8,9);1H2,2H3;;/q;;2*+1/p-2

InChI key

RTKIYNMVFMVABJ-UHFFFAOYSA-L

agency

BP
Ph. Eur.

product line

EMPROVE® ESSENTIAL

form

solid

pH

6.7 (20 °C, 10 g/L in H2O)

mp

232-233 °C (decomposition)

transition temp

flash point 250 °C

solubility

1000 g/L

application(s)

liquid formulation
ophthalmics
pharma/biopharma processes
pharmaceutical
semi-solid formulation

storage temp.

15-25°C

Quality Level

Application

Thimerosal has strong antiseptic and antifungal capabilities and is therefore typically used as preservative in liquid dosage forms of cosmetics and pharmaceutical products.

Disclaimer

As part of the corporation global plan to support the MinamataConvention in eliminating mercury-containing compounds, as of January 2021customers will be required to provide an End-Use Declaration. The sales ofthimerosal will be restricted for approved applications only, such aspreservative in vaccine manufacturing, preservative in eye cosmetics, researchuse within academia (excluding preservation intent) and as reference materialonly. The product is not intended for use as a biocide under global biocideregulations, including but not limited to US EPA′s Federal InsecticideFungicide and Rodenticide Act , European Biocidal Products Regulation, Canada’sPest Management Regulatory Agency, Turkey’s BiocidalProducts Regulation, Korea’s Consumer Chemical Products and BiocideSafety Management Act (K-BPR) and others.
For U.S. Customers: Contains mercury; Do not place in trash - dispose according to local, state, or federal laws.

General description

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

signalword

Danger

Hazard Classifications

Acute Tox. 1 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - STOT RE 2 Oral

target_organs

Kidney

存储类别

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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Find key considerations for the selection and use of preservatives in a range of different therapeutic applications including topical, oral, transmucosal, inhalation, and otic, as well as injectables.

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