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Merck
CN

8.52111

Fmoc-Lys(Me)2-OH HCl

≥95.0% (HPLC), for peptide synthesis, Novabiochem®

别名:

Fmoc-Lys(Me)₂-OH HCl, N-α-Fmoc-N-ε-dimethyl-N-L-lysine · hydrochloride

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关于此项目

经验公式(希尔记法):
C23H28N2O4 · xHCl
化学文摘社编号:
分子量:
396.48 (free base basis)
MDL number:
UNSPSC Code:
12352209
NACRES:
NA.22
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产品名称

Fmoc-Lys(Me)2-OH HCl, Novabiochem®

Quality Level

product line

Novabiochem®

assay

≥95% (TLC), ≥95.0% (HPLC)

form

powder

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

manufacturer/tradename

Novabiochem®

application(s)

peptide synthesis

functional group

amine

storage temp.

-10 to -25°C

SMILES string

Cl.N([C@@H](CCCCN(C)C)C(=O)O)C(=O)OCC1c2c(cccc2)c3c1cccc3

InChI

1S/C23H28N2O4.ClH/c1-25(2)14-8-7-13-21(22(26)27)24-23(28)29-15-20-18-11-5-3-9-16(18)17-10-4-6-12-19(17)20;/h3-6,9-12,20-21H,7-8,13-15H2,1-2H3,(H,24,28)(H,26,27);1H/t21-;/m0./s1

InChI key

SJFAFKDBWNFBCC-BOXHHOBZSA-N

General description

A novel derivative for the introduction of dimethyl-lysine during Fmoc SPPS. Ref [1] contains methods and protocols for the synthesis of arrays of histone-related peptides containing methylated arginine and lysine-residues.


Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS
Overcoming Aggregation in Fmoc SPPS

Literature references

[1] S. Rothbart, et al. (2012) Methods Enzymol., 512, 107.

Analysis Note

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Enantiomeric purity: ≥ 99.5 % (a/a)
Purity (TLC(CMA1)): ≥ 95 %
Assay (HPLC, area%): ≥ 95.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clearly soluble
Acetate (IC): ≤ 1.0 %

To see the solvent systems used for TLC of Novabiochem® products please click here.

Other Notes

Replaces: 04-12-1269

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany


存储类别

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable



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实验方案

We provide an overview of our available reagents, together with recommendations and details of their use for synthesis of peptides containing post-translationally modified amino acids.

商品

Unnatural amino acids, the non-proteinogenic amino acids that either occur naturally or are chemically synthesized, are becoming more and more important as tools for modern drug discovery research.





全球贸易项目编号

货号GTIN
852111850004027269135188
852111000504027269089801
852111000104027269089795