AB10911
抗骨钙素抗体
serum, from rabbit
别名:
Bone Gla protein, Gamma-carboxyglutamic acid-containing protein, bone gamma-carboxyglutamate (gla) protein (osteocalcin)
产品名称
抗骨钙素抗体, serum, from rabbit
biological source
rabbit
conjugate
unconjugated
antibody form
serum
antibody product type
primary antibodies
clone
polyclonal
species reactivity
human, rat, mouse
technique(s)
immunohistochemistry: suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... BGLAP(632)
mouse ... Bglap(12096)
rat ... Bglap(25295)
Analysis Note
通过蛋白质印迹法对人心脏裂解液进行常规评估。
蛋白质印迹分析：
该抗体的1:500 - 1:5,000稀释液在10 μg人心脏裂解液中检测到骨钙素。
蛋白质印迹分析：
该抗体的1:500 - 1:5,000稀释液在10 μg人心脏裂解液中检测到骨钙素。
Application
使用经过验证可用于WB、IH的抗骨钙素抗体检测骨钙素。
Biochem/physiol Actions
抗体与骨钙素蛋白反应。
General description
计算值为11 kDa。
*观察到约22 kDa的条带。观察到的条带与预期条带之间的差异可能是由于翻译后修饰所致。
*观察到约22 kDa的条带。观察到的条带与预期条带之间的差异可能是由于翻译后修饰所致。
骨钙素属于骨钙素/基质Gla蛋白家族。占骨蛋白总量的1~2%。它由成骨细胞制成，是非胶原骨基质的主要成分。它对钙具有高亲和力，并与磷灰石牢固结合。60%至90%的从头合成的骨钙素被掺入骨基质中，在基质矿化过程中它与羟基磷灰石结合。骨钙素的其余部分释放到循环中，可以作为骨形成的敏感标志物进行测量。血清中发现的骨钙素几乎完全来自骨形成，而吸收过程几乎没有贡献。主要作用于骨吸收的药物，例如双膦酸盐，会引起特定骨吸收标志物的快速下降，而骨钙素水平仅在延长治疗期后才会发生变化，这与骨形成标志物的预期动力学一致。在以骨转换增加为特征的疾病（例如骨质疏松症症、甲状旁腺功能亢进症症和Paget′s病）中，血清骨钙素水平升高；在与骨转换减少相关的疾病（例如甲状旁腺功能减退症症和生长激素缺乏症症）中，血清骨钙素水平降低。
Immunogen
合成肽对应于骨钙素蛋白的aa 59-74。
表位：aa 59-74
Other Notes
替代品：MABD182
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存储类别
10 - Combustible liquids
wgk
WGK 1
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