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Merck
CN

FCMAB317PE

Milli-Mark® 抗-NeuN-PE抗体，克隆A60

clone A60, Milli-Mark®, from mouse

别名:

Neuron-Specific Nuclear Protein, Neuna60, A60

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关于此项目

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
PE
Clone:
A60, monoclonal
Application:
flow cytometry
Species reactivity:
human
Citations:
35
Technique(s):
flow cytometry: suitable

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产品名称

Milli-Mark® 抗-NeuN-PE抗体，克隆A60, clone A60, Milli-Mark®, from mouse

biological source

mouse

conjugate

PE

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

A60, monoclonal

species reactivity

human

manufacturer/tradename

Milli-Mark®

technique(s)

flow cytometry: suitable

isotype

IgG1

shipped in

wet ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... RBFOX3(146713)

相关类别

Analysis Note

使用U251细胞通过流式细胞仪进行评价。
对照
U251细胞

Application

研究子类别
神经 & 胶质标记
研究类别
神经科学
经验证，该Milli-Mark Anti-NeuN-PE抗体（克隆A60）可用于FC检测NeuN。

Biochem/physiol Actions

抗体识别神经元核。

Disclaimer

除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

General description

NeuN抗体（神经元核；克隆A60）可特异性地识别DNA结合的神经元特异性蛋白NeuN，它存在于所有被测脊椎动物的大多数CNS和PNS神经元细胞中。NeuN蛋白的分布明显局限于胎儿和成人大脑中的神经元细胞核、核周体和一些近端神经元突起，但有些神经元在所有年龄段都不能被NeuN识别：例如，INL视网膜细胞、Cajal Retzius细胞、浦肯野细胞、下橄榄核和齿状核神经元以及交感神经节细胞（Mullen et al., 1992; Wolf et al., 1996）。免疫组化检测的NeuN蛋白首先出现在神经元从细胞周期中退出和/或与神经元终末分化开始所对应的发育时间点（Mullen et al., 1992）。免疫反应性出现在小鼠神经管中的E9.5附近，广泛存在于E12.5发育中的神经系统中。

Immunogen

纯化小鼠脑细胞核。

Physical form

在含0.1％叠氮化钠和15 mg/mL BSA的PBS中的PE偶联的纯化的小鼠单克隆IgG1。
纯化的蛋白 A

Preparation Note

自收到之日起，在2-8°C下以未稀释等分试样形式可避光冷藏6个月。

Legal Information

MILLI-MARK is a registered trademark of Merck KGaA, Darmstadt, Germany

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存储类别

10 - Combustible liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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Kathryn Vaillancourt et al.
iScience, 24(10), 103169-103169 (2021-10-26)
Cocaine dependence is a chronic, relapsing disorder caused by lasting changes in the brain. Animal studies have identified cocaine-related alterations in striatal DNA methylation; however, it is unclear how methylation is related to cocaine dependence in humans. We generated methylomic
Jeffrey Gu et al.
Frontiers in neuroscience, 15, 652226-652226 (2021-05-18)
Parkinson's disease (PD) and dementia with Lewy body (DLB) are the most common synucleinopathies. SNCA gene is a major genetic risk factor for these diseases group, and dysregulation of its expression has been implicated in the genetic etiologies of several
Federico Abascal et al.
Nature, 593(7859), 405-410 (2021-04-30)
Somatic mutations drive the development of cancer and may contribute to ageing and other diseases1,2. Despite their importance, the difficulty of detecting mutations that are only present in single cells or small clones has limited our knowledge of somatic mutagenesis
Julio Barrera et al.
Molecular neurodegeneration, 16(1), 58-58 (2021-08-26)
In the post-GWAS era, there is an unmet need to decode the underpinning genetic etiologies of late-onset Alzheimer's disease (LOAD) and translate the associations to causation. We conducted ATAC-seq profiling using NeuN sorted-nuclei from 40 frozen brain tissues to determine
Alexey Kozlenkov et al.
Science advances, 4(9), eaau6190-eaau6190 (2018-09-29)
Brain function depends on interaction of diverse cell types whose gene expression and identity are defined, in part, by epigenetic mechanisms. Neuronal DNA contains two major epigenetic modifications, methylcytosine (mC) and hydroxymethylcytosine (hmC), yet their cell type-specific landscapes and relationship
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