产品名称
抗整合素α5抗体，克隆P1D6，无叠氮化物, clone P1D6, Chemicon®, from mouse
biological source
mouse
Quality Level
antibody form
purified antibody
antibody product type
primary antibodies
clone
P1D6, monoclonal
species reactivity
human
manufacturer/tradename
Chemicon®
technique(s)
immunohistochemistry: suitable
isotype
IgG3
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... ITGA5(3678)
General description
整合素α 5属于整合素α链家族。整合素是由α链和β链组成的异二聚体整合膜蛋白。该基因编码整合素α 5链。α链5在胞外区进行翻译后裂解，产生与β1结合形成纤维连接蛋白受体的二硫键连接轻链和重链。除粘连外，已知整合素参与细胞表面介导的信号传导。
Application
MAB1956Z适用于成纤维细胞、内皮细胞、血小板和T&B淋巴细胞对纤维连接蛋白的附着抑制试验。
MAB1956Z与变性α 5亚基无反应性。 对于免疫印迹，建议以斑点印迹作为蛋白质印迹的替代方法。
MAB1956Z与变性α 5亚基无反应性。 对于免疫印迹，建议以斑点印迹作为蛋白质印迹的替代方法。
研究子类别
整合素
整合素
研究类别
细胞结构
细胞结构
该抗整合素α5抗体（克隆P1D6，无叠氮化物）经验证可用于IH、FUNC中整合素α5的检测。
Biochem/physiol Actions
与人α 5整合素反应。 与其他物种的反应性尚不可知。
Physical form
形式：纯化
纯化小鼠单克隆，溶于0.01M磷酸盐、150mM NaCl，pH 7.4，不含防腐剂。
纯化蛋白A
Preparation Note
自发运之日起，在 2–8°C 条件下可稳定保存 1 年等分以避免反复冻融。为了最大程度地回收产品，在融化后和取下盖子之前，将原始小瓶进行离心。
Analysis Note
对照
广泛表达，卵巢
广泛表达，卵巢
Other Notes
浓度：请参考批次特异性浓缩物的检验报告。
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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存储类别
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
John J Grzesiak et al.
Surgery, 141(6), 804-814 (2007-06-15)
We have shown recently that alpha(2)beta(1) integrin-mediated type I collagen adhesion promotes a more malignant phenotype in pancreatic cancer cell lines than other extracellular matrix (ECM) proteins. MiaPaCa-2 cells, by contrast, do not express collagen-binding integrins, but are metastatic in
Manish K Rana et al.
Journal of cell science, 128(6), 1083-1089 (2015-01-27)
Increased production and assembly of extracellular matrix proteins during transdifferentiation of epithelial cells to a mesenchymal phenotype contributes to diseases such as renal and pulmonary fibrosis. TGF-β and hypoxia, two cues that initiate injury-induced fibrosis, caused human kidney cells to
Meng Lu et al.
Hepatology (Baltimore, Md.), 68(1), 317-332 (2018-01-23)
Hepatocytes are epithelial cells with highly specialized polarity. The disorder and loss of hepatocyte polarity leads to a weakness of cell adhesion and connection, the induction of epithelial-mesenchymal transition, and eventually the occurrence of hepatocellular carcinoma (HCC). Cluster of differentiation
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| MAB1956Z | 04053252610004 |