MAB3303
抗VI型胶原抗体，克隆VI-26
clone VI-26, Chemicon®, from mouse
别名:
Anti-BTHLM1, Anti-OPLL, Anti-UCHMD1
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
VI-26, monoclonal
Application:
ELISA, IHC
Citations:
28
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
VI-26, monoclonal
species reactivity
human, rabbit
should not react with
rat
manufacturer/tradename
Chemicon®
availability
not available in Japan
technique(s)
ELISA: suitable, immunohistochemistry: suitable (paraffin)
isotype
IgG1κ
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... COL6A1(1291)
Application
丙酮固定石蜡包埋组织的免疫组化。不建议福尔马林固定。 抗原回收在非特异性过氧化物酶阻断前用0.04%胰蛋白酶在0.01 M CaCl（2）0.05 M Tris-HCL pH值7.6，37°C中处理10分钟。
EIA
最佳工作稀释度必须由最终用户确定。
EIA
最佳工作稀释度必须由最终用户确定。
已发表抗VI型胶原抗体，克隆VI-26可检测VI&型胶原水平，&经验证可用于ELISA，IH（P）。
研究子类别
ECM 蛋白
ECM 蛋白
研究类别
细胞结构
细胞结构
Biochem/physiol Actions
与hCL（VI）发生特异性反应。 这是抗人VI型胶原的纯化小鼠单克隆抗体。VI-26不与变性或还原的VI型胶原反应，尽管该抗体确实识别由α1（VI），α2（VI）α3（γ）组成的三螺旋。 表位尚未定位，并且已知单克隆抗体在天然测定中不会与胶原I、II、III、IV或V反应。
Physical form
形式：纯化
液体溶于0.1 M磷酸钠缓冲液，pH值7.0含有2%无蛋白酶的牛血清白蛋白。
纯化的蛋白 A
Preparation Note
自发运之日起在-20°C可保存1年。等分以避免反复冻融。为了最大程度地回收产品，在融化后和取下盖子之前，将原始样品瓶进行离心。
Analysis Note
对照
睾丸，结缔组织
睾丸，结缔组织
Other Notes
浓度：请参考批次特异性浓缩物的分析证书。
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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存储类别
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Te-Cheng Pan et al.
American journal of human genetics, 73(2), 355-369 (2003-07-04)
Recessive mutations in two of the three collagen VI genes, COL6A2 and COL6A3, have recently been shown to cause Ullrich congenital muscular dystrophy (UCMD), a frequently severe disorder characterized by congenital muscle weakness with joint contractures and coexisting distal joint
Laura Briñas et al.
Annals of neurology, 68(4), 511-520 (2010-10-27)
Mutations in the genes encoding the extracellular matrix protein collagen VI (ColVI) cause a spectrum of disorders with variable inheritance including Ullrich congenital muscular dystrophy, Bethlem myopathy, and intermediate phenotypes. We extensively characterized, at the clinical, cellular, and molecular levels
Russell J Butterfield et al.
Human mutation, 34(11), 1558-1567 (2013-09-17)
Glycine substitutions in the conserved Gly-X-Y motif in the triple helical (TH) domain of collagen VI are the most commonly identified mutations in the collagen VI myopathies including Ullrich congenital muscular dystrophy, Bethlem myopathy, and intermediate (INT) phenotypes. We describe
Russell J Butterfield et al.
PloS one, 12(12), e0189664-e0189664 (2017-12-16)
The collagen VI related muscular dystrophies (COL6-RD), Ullrich congenital muscular dystrophy (UCMD) and Bethlem myopathy (BM) are among the most common congenital muscular dystrophies and are characterized by distal joint laxity and a combination of distal and proximal joint contractures.
D O Visscher et al.
Journal of biomedical materials research. Part B, Applied biomaterials, 107(5), 1711-1721 (2018-11-02)
The aim of this study was to design and manufacture an easily assembled cartilage implant model for auricular reconstruction. First, the printing accuracy and mechanical properties of 3D-printed poly-ε-caprolactone (PCL) scaffolds with varying porosities were determined to assess overall material
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