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Merck
CN

MAB3328

抗MMP-14抗体，催化域，克隆LEM-2 / 15.8

clone LEM-2/15.8, Chemicon®, from mouse

别名:

MT1-MMP

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关于此项目

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702

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产品名称

抗MMP-14抗体，催化域，克隆LEM-2 / 15.8, clone LEM-2/15.8, Chemicon®, from mouse

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

LEM-2/15.8, monoclonal

species reactivity

mouse, human

packaging

antibody small pack of 25 μg

manufacturer/tradename

Chemicon®

technique(s)

ELISA: suitable
immunoprecipitation (IP): suitable
western blot: suitable

isotype

IgG1κ

NCBI accession no.

NM_004995.2

UniProt accession no.

P50281

shipped in

ambient

storage temp.

2-8°C

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... MMP14(4323)

相关类别

Application

研究类别
细胞结构
使用该抗 MMP-14 抗体（催化域，克隆 LEM-2/15.8，经验证可用于 ELISA、IP & WB）检测 MMP-14。
研究子类别
MMPs & TIMPs
蛋白质印迹

免疫组化：冷冻和石蜡包埋的组织

免疫荧光

流式细胞术

封闭：10-15μg/mL

最佳工作稀释度必须由最终用户确定。

Biochem/physiol Actions

LEM-2/15.8 与人 MT1-MMP 发生反应，并与小鼠标本产生交叉反应。 该抗体是针对 MT1-MMP 的催化结构域生成的，能够抑制酶的活性。

Disclaimer

除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

General description

MT1-MMP 在内皮细胞迁移和基质重塑中起着重要作用。 尽管 MT1-MMP 在内皮细胞运动中的作用尚未完全阐明，但它的活性似乎在血管生成反应期间调节内皮的迁移、侵袭和毛细管的形成（Galvez，2001）。 Mt1-MMP 在炎症过程中的单核细胞再生中也起着关键作用（Salomon，2005）。

Immunogen

合成肽：催化结构域内的氨基酸序列 218-233
表位：催化结构域

Other Notes

浓度：请参考批次特异性浓缩物的分析证书。

Physical form

形式：纯化的
通过蛋白 A 层析纯化的免疫球蛋白。 溶于 0.2M 磷酸盐，0.25M NaCl，pH 7.6 的液体，含有 0.1％ 叠氮化钠。

Preparation Note

自收到之日起，置于 2° 至 8°C 最多可保存 12 个月。

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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存储类别

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

分析证书(COA)

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G Daniel Grass et al.
Journal of cell science, 125(Pt 3), 777-788 (2012-03-06)
A defining feature of malignant tumor progression is cellular penetration through the basement membrane and interstitial matrices that separate various cellular compartments. Accumulating evidence supports the notion that invasive cells employ specialized structures termed invadopodia to breach these structural barriers.
Karina Di Gregoli et al.
Arteriosclerosis, thrombosis, and vascular biology, 34(9), 1990-2000 (2014-07-06)
Our recent studies have highlighted membrane type-1 matrix metalloproteinase (MMP)-14 as a selective marker for an invasive subset of macrophages potentially related to atherosclerotic plaque progression. Moreover, colony stimulating factors (CSF) may exert divergent effects on macrophage MMP expression, possibly
J K Björk et al.
Oncogene, 35(14), 1770-1784 (2015-06-30)
Heat-shock factors (HSFs) are key transcriptional regulators in cell survival. Although HSF1 has been identified as a driver of carcinogenesis, HSF2 has not been explored in malignancies. Here, we report that HSF2 suppresses tumor invasion of prostate cancer (PrCa). In
Charles Marusak et al.
Pharmacological research, 113(Pt A), 515-520 (2016-10-21)
MT1-MMP and MMP2 have been implicated as pro-tumorigenic and pro-metastatic factors in a wide variety of cancers including melanoma. We have previously demonstrated that MT1-MMP is highly expressed in melanoma where it promotes melanoma cell invasion and metastasis in part
Aoife Kelly et al.
The Journal of experimental medicine, 215(11), 2725-2736 (2018-10-26)
Monocytes are crucial immune cells involved in regulation of inflammation either directly or via differentiation into macrophages in tissues. However, many aspects of how their function is controlled in health and disease are not understood. Here we show that human
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相关内容

MOUSE ANTI-MMP-14 [MT1-MMP] MONOCLONAL ANTIBODY
Fluorescent Gelatin Degradation Assays for Investigating Invadopodia Formation

QCM™ Gelatin Invadopodia Assays provide optimized materials and protocols to enable reproducible analysis of invadopodia in invasive tumor cells (Catalog No. ECM670 for green fluorescence, Catalogue No. ECM671 for red fluorescence). Reagents are provided for coating glass culture surfaces with fluorescent matrix and for colocalizing the actin cytoskeleton and nuclei with invadopodial degradation sites. This assay may also be used for assessing the activity of inhibitors and promoters of invadopodia formation and function. Furthermore, different cell types and individual cells in heterogeneous populations may be analyzed for invasive potential. Finally, the assay kits provide troubleshooting suggestions, recommendations for coating on multiple substrate formats, and example studies in several assay systems (e.g., various cell types, time-course studies, degradation modulation).

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