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MAB365

抗-神经生长因子受体抗体,细胞外,克隆192-IgG

clone 192-IgG, Chemicon®, from mouse

别名:

CD271 antigen, Low affinity neurotrophin receptor p75NTR, Low-affinity nerve growth factor receptor, NGF receptor, low affinity nerve growth factor receptor, nerve growth factor receptor, nerve growth factor receptor (TNFR superfamily, member 16), p75 IC

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关于此项目

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
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产品名称

抗-神经生长因子受体抗体,细胞外,克隆192-IgG, clone 192-IgG, Chemicon®, from mouse

biological source

mouse

conjugate

unconjugated

antibody form

purified antibody

antibody product type

primary antibodies

clone

192-IgG, monoclonal

species reactivity

rat

manufacturer/tradename

Chemicon®

technique(s)

immunocytochemistry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

isotype

IgG1

NCBI accession no.

UniProt accession no.

shipped in

wet ice

target post-translational modification

unmodified

Quality Level

Gene Information

human ... NGFR(4804)

Application

抗神经生长因子受体抗体,细胞外,克隆192-IgG是用于IC、IH、IP、FUNC&WB的抗神经生长因子受体的抗体。
研究子类别
神经化学&神经营养蛋白
研究类别
神经科学
蛋白质印迹法:
1-5 µg/mL(仅非还原条件)用于先前的批次。

抑制测定:
对NGF结合的抑制{Chandler,1984}。

免疫沉淀:
5 µg/mL,0.5% Triton X-100缓冲液;PC12阳性对照用于先前批次。

免疫组织化学:
使用1-5 µg/mL的先前批次用于大鼠脊髓。也可用其他固定剂和方法。

Analysis Note

对照
蛋白质印迹法:NGF分化的PC12细胞裂解物。
免疫组织化学:大鼠脑组织。
免疫组织化学:
1-5 µg/mL的先前批次用于大鼠(脊髓,见下文方案);也可用其他固定剂和方法。

Biochem/physiol Actions

与大鼠p75蛋白反应。
对大鼠低亲和力神经生长因子受体(p75)具有特异性,不与人或小鼠p75反应。

Disclaimer

除非我们的目录或产品随附的其他公司文件中另有说明,否则我们的产品预期仅用于研究用途,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或对人类或动物的任何类型的消费或应用。

General description

75 kDa
低亲和力NGFR(神经生长因子受体)是一种75kDa的跨膜糖蛋白,缺乏内在的酪氨酸激酶活性。p75NGFR与高亲和力NGF受体TrkA相互作用,并在低NGF浓度下增强TrkA信号传导。p75受体以不同的特异性结合神经生长因子、脑源性神经营养蛋白、神经营养蛋白3和神经营养蛋白4。p75NGFR在神经营养蛋白信号传导中起重要作用,并已显示出可调节选择性细胞群体对程序性细胞死亡的敏感性。它在许多类型的神经元细胞上表达,包括许多胚胎形式,并且该受体可用于分离神经元祖细胞。

Immunogen

从PC-12细胞质膜中分离的含有p75受体的N-辛葡糖苷稳定蛋白(Chandler et al.,1984)。
表位:细胞外

Other Notes

替代:04-1111
浓度:关于批次特定浓度请参见检验报告。

Physical form

小鼠单克隆IgG1,溶于0.02 M磷酸盐缓冲液(pH7.6)、0.25 M NaCl和0.1%叠氮化钠中
形式:纯化
纯化蛋白A

Preparation Note

自接收之日起,在2-8ºC下可稳定保存1年。

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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存储类别

10 - Combustible liquids

wgk

WGK 2


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European journal of immunology, 31(1), 11-22 (2001-02-13)
In order to analyze a putative immunomodulatory effect of NGF in experimental autoimmune encephalomyelitis (EAE) of the Lewis rat, we transduced myelin basic protein (MBP)-specific CD4(+) T cells with a recombinant retrovirus encoding NGF. These T(MBP)NGF cells secreted high levels
Mary Ann Asson-Batres et al.
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Tara Lovekamp-Swan et al.
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Estrogen is a powerful neuroprotective agent with the ability to induce trophic and antiapoptotic genes. However, concerns about negative overall health consequences of estrogen replacement after menopause have led to the adoption of other strategies to obtain estrogen's benefits in
Ying Li et al.
Cell transplantation, 25(2), 293-299 (2015-07-02)
Cell transplantation is one of the most promising strategies for repair of human spinal cord injuries. Animal studies from a number of laboratories have shown that transplantation of olfactory ensheathing cells cultured from biopsies of the olfactory bulb mediate axonal

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