MABN328
抗-肽基瓜氨酸，克隆F95抗体
clone F95, from mouse
别名:
Peptidyl-citrulline, Protein-bound citrulline
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Clone:
F95, monoclonal
Species reactivity:
mouse, rat, chicken, human
Application:
ICC, IHC, WB
Citations:
53
biological source
mouse
antibody form
purified antibody
antibody product type
primary antibodies
clone
F95, monoclonal
species reactivity
mouse, rat, chicken, human
species reactivity (predicted by homology)
all (based on 100% sequence homology)
technique(s)
immunocytochemistry: suitable, immunohistochemistry: suitable, western blot: suitable
isotype
IgMκ
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
General description
脱亚胺（瓜氨酸化）是一种翻译后修饰，其中肽基-精氨酸脱亚胺酶家族将氨基酸精氨酸的胍基侧链转化为脲基，即产生肽基-瓜氨酸。因此，抗肽基瓜氨酸抗体也应与赖氨酸氨甲酰化产生的肽基高瓜氨酸发生交叉反应，但不与尿素循环中产生的游离瓜氨酸或一氧化氮合成的副产物游离瓜氨酸发生交叉反应。
计算的各种kDa
Immunogen
瓜氨酸化肽，由10个瓜氨酸残基和一个羧基Gly-Gly-Cys组成。
Application
免疫组织化学分析：一个代表性批次以1:250稀释度在人小脑和大鼠小脑组织中检测到肽基瓜氨酸。
蛋白质印迹分析：一个代表性批次在EAE小鼠的大脑和脊髓的CNS蛋白中检测到肽基瓜氨酸（Nicholas等，2005）。
蛋白质印迹分析：一个代表性批次在EAE小鼠的大脑和脊髓的CNS蛋白中检测到肽基瓜氨酸（Nicholas等，2005）。
研究子类别
神经退行性疾病
神经退行性疾病
研究类别
神经科学
神经科学
该抗肽基瓜氨酸克隆F95抗体经验证可用于免疫组织化学、蛋白质印迹和免疫细胞化学检测肽基瓜氨酸。
Physical form
形式：纯化
纯化的小鼠单克隆IgMκ，溶于含0.05%叠氮化钠的PBS的缓冲液中。
Preparation Note
自接收之日起，在2-8°C下可稳定保存1年。
Analysis Note
通过免疫组织化学在人大脑皮层组织中进行评估。
免疫组织化学分析：该抗体以1:250稀释度在人大脑皮层组织中检测到肽基瓜氨酸。
免疫组织化学分析：该抗体以1:250稀释度在人大脑皮层组织中检测到肽基瓜氨酸。
Other Notes
浓度：请参考特定批次的数据表。
Disclaimer
除非我们的目录或产品随附的其他公司文件中另有说明，否则我们的产品预期仅用于研究用途，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或对人类或动物的任何类型的消费或应用。
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存储类别
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Marianne Engström et al.
Journal of translational medicine, 16(1), 214-214 (2018-08-02)
A relationship between rheumatoid arthritis (RA) and periodontitis has been suggested from findings that individuals with RA are prone to have advanced periodontitis and vice versa. In search of possible common pathogenetic features of these two diseases, we investigated the
Jill A Poole et al.
Respiratory research, 18(1), 214-214 (2017-12-24)
Agriculture organic dust exposures induce lung disease with lymphoid aggregates comprised of both T and B cells. The precise role of B cells in mediating lung inflammation is unknown, yet might be relevant given the emerging role of B cells
Robby Engelmann et al.
PloS one, 11(6), e0158773-e0158773 (2016-07-01)
To assess the prerequisites for negative selection of peptidylcitrulline-specific T cells in the thymus. In detail, we here analyzed murine medullary thymic epithelial cells for the expression of peptidylarginine deiminases (PAD) and subsequent citrullination. Medullary thymic epithelial cells were sorted
R Bright et al.
Journal of periodontal research, 53(1), 139-143 (2017-10-19)
Postranslational modification of proteins can lead to the production of autoantibodies and loss of immune tolerance. This process has been hypothesised to be a critical factor in the pathogenesis of rheumatoid arthritis. The objective of this study was to demonstrate
Caitlyn L Holmes et al.
PloS one, 14(5), e0217221-e0217221 (2019-05-29)
The antibody response to pertussis vaccination in rheumatoid arthritis is unknown, a concerning omission given the relatively low efficacy of the pertussis vaccine, a rise in pertussis infections, and a general increased susceptibility to infection in rheumatoid arthritis. Additionally, the
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