MABN41
抗-钠通道Nav1.7抗体，克隆N68/6
clone N68/6, from mouse
别名:
sodium channel, voltage-gated, type IX, alpha subunit, Sodium channel protein type IX subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.7, Peripheral sodium channel 1, sodium channel, voltage-gated, type IX, alpha polypeptide, Nav1.7, sodium
产品名称
抗-钠通道Nav1.7抗体，克隆N68/6, clone N68/6, from mouse
biological source
mouse
conjugate
unconjugated
antibody form
purified antibody
antibody product type
primary antibodies
clone
N68/6, monoclonal
species reactivity
rat, human
technique(s)
immunohistochemistry: suitable
western blot: suitable
isotype
IgG1κ
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Application
该抗钠通道Nav1.7抗体（克隆N68/6）经验证可用于IH、WB中钠通道Nav1.7的检测。
研究子类别
信号神经科学
信号神经科学
研究类别
神经科学
信号传导
神经科学
信号传导
蛋白质印迹分析： 一个先前批次已被独立实验室用于HEK293细胞裂解物。（James Trimmer，UC Davis/NIH NeuroMab Facility，神经生物学、生理学和行为学系，UC Davis，Davis CA 95616-8519。neuromab@ucdavis.edu.）
Analysis Note
对照
大鼠小脑组织
大鼠小脑组织
通过免疫组织化学在大鼠小脑组织中进行评价。
免疫组织化学分析：该抗体以1:400稀释度在大鼠小脑组织中检测到Nav1.7。
免疫组织化学分析：该抗体以1:400稀释度在大鼠小脑组织中检测到Nav1.7。
Disclaimer
除非我们的目录或产品随附的其他公司文件中另有说明，否则我们的产品预期仅用于研究用途，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或对人类或动物的任何类型的消费或应用。
General description
在约230 kDa处观察到
电压门控钠通道亚基αNav1.7（Nav1.7）是一种多通道膜蛋白，包含属于钠通道家族的单个IQ结构域。Nav1.7定位于感觉神经元的末端，并被认为在炎症性疼痛的发展和机制中起作用。它用于调节可激发的膜电压依赖性Na+离子渗透性。Nav1.7极有可能参与伤害性信息的传递，这种暗示的参与是由于其在由周围神经损伤引起的多种慢性疼痛神经病中的作用所支持的。Nav1.7主要在背根神经节、感觉和交感神经元中观察到。在MTC细胞系、C细胞癌和平滑肌细胞中观察到较低水平的蛋白质。Nav1.7表达的缺陷与多种疾病有关，例如常染色体隐性先天性冷漠性疼痛、原发性红热病和阵发性极度疼痛或PEPD。
Immunogen
对应于人Nav1.7的重组蛋白。
Other Notes
浓度：关于批次特定浓度请参见检验报告。
Physical form
形式：纯化
纯化的小鼠单克隆IgG1κ，溶于含0.1 M Tris-甘氨酸（pH 7.4）、150 mM NaCl和0.05%叠氮化钠的缓冲液中。
蛋白G
Preparation Note
自接收之日起，在2-8°C下可稳定保存1年。
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Fei Dong et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 40(50), 9589-9601 (2020-11-12)
Itch can be induced by activation of small-diameter DRG neurons, which express abundant intracellular fibroblast growth factor 13 (FGF13). Although FGF13 is revealed to be essential for heat nociception, its role in mediating itch remains to be investigated. Here, we
Assembly and validation of versatile transcription activator-like effector libraries.
Li, Y; Ehrhardt, K; Zhang, MQ; Bleris, L
Scientific Reports null
Raquel Talens-Visconti et al.
Journal of neurochemistry, 112(4), 1074-1087 (2009-12-09)
Neurite formation involves coordinated changes between the actin cytoskeleton and the microtubule network. Rho GTPases are clearly implicated in several aspects of neuronal development and function. Indeed, RhoA is a negative regulator of neurite outgrowth and its effector Rho-kinase mediates
Dong Liu et al.
F1000Research, 5, 2764-2764 (2016-12-19)
Identification of small and large molecule pain therapeutics that target the genetically validated voltage-gated sodium channel Na V1.7 is a challenging endeavor under vigorous pursuit. The monoclonal antibody SVmab1 was recently published to bind the Na V1.7 DII voltage sensor
Liu Yang et al.
Neuron, 93(4), 806-821 (2017-02-07)
The current knowledge about heat nociception is mainly confined to the thermosensors, including the transient receptor potential cation channel V1 expressed in the nociceptive neurons of dorsal root ganglion (DRG). However, the loss of thermosensors only partially impairs heat nociception
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