MABN613
Anti-Potassium channel Kv2.1 Antibody, clone L80/21
clone L80/21, from mouse
别名:
Potassium voltage-gated channel subfamily B member 1, Delayed rectifier potassium channel 1, DRK1, Voltage-gated potassium channel subunit Kv2.1
生物来源
mouse
抗体形式
purified antibody
抗体产品类型
primary antibodies
克隆
L80/21, monoclonal
种属反应性
rat, mouse
技术
immunohistochemistry: suitable (paraffin)
western blot: suitable
同位素/亚型
IgG3κ
NCBI登记号
UniProt登记号
运输
wet ice
靶向翻译后修饰
unmodified
基因信息
mouse ... Kcnb1(16500)
一般描述
Voltage-gated potassium channel subunit Kv2.1 (Kv2.1) is also called potassium voltage-gated channel subfamily B member 1 (KCNB1) or delayed rectifier potassium channel 1 (DRK1). Kv2.1 is a voltage-gated potassium ion channel that is expressed in the brain (cell bodies and dendrites of neurons but not axons, as well as Schwann cells), atria, ventricle, skeletal muscle, cochlea, retina, lung and pulmonary arteries. It is involved in maintaining membrane potential and modulating electrical excitability of both neurons and muscle cells. It is thought that Kv2.1 has a role in the muscle tone of the pulmonary system, as the expression Kv2.1 in pulmonary smooth muscle has been found to be reduced in chronic hypoxic pulmonary hypertension.
~95 kDa observed
免疫原
Epitope: C-terminus
Linear peptide corresponding to the C-terminus of rat Potassium channel Kv2.1.
应用
Detect Kv2.1 using this mouse monoclonal antibody, Anti-Potassium channel Kv2.1 Antibody, clone L80/21 validated for use in western blotting & IHC (Paraffin).
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Potassium channel Kv2.1 in rat frontal cortex tissue.
Western Blotting Analysis: A representative lot detected Potassium channel Kv2.1 in wild type mouse brain membrane tissue lysate, and demonstrated a loss of signal in Potassium channel Kv2.1 knock out mouse brain membrante tissue lysate (Prof. J. Trimmer, University of California, Davis.).
Western Blotting Analysis: A representative lot detected Potassium channel Kv2.1 in wild type mouse brain membrane tissue lysate, and demonstrated a loss of signal in Potassium channel Kv2.1 knock out mouse brain membrante tissue lysate (Prof. J. Trimmer, University of California, Davis.).
Research Category
Neuroscience
Neuroscience
Research Sub Category
Synapse & Synaptic Biology
Synapse & Synaptic Biology
生化/生理作用
This antibody recognizes the C-terminus of Potassium channel Kv2.1.
外形
Protein G Purified
Format: Purified
Purified mouse monoclonal IgG3κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
制备说明
Stable for 1 year at 2-8°C from date of receipt.
分析说明
Control
Rat brain tissue lysate
Rat brain tissue lysate
Evaluated by Western Blotting in rat brain tissue lysate.
Western Blotting Analysis: 1 µg/mL of this antibody detected Potassium channel Kv2.1 in 10 µg of rat brain tissue lysate.
Western Blotting Analysis: 1 µg/mL of this antibody detected Potassium channel Kv2.1 in 10 µg of rat brain tissue lysate.
其他说明
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
12 - Non Combustible Liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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