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Merck
CN

MABN613

Sigma-Aldrich

Anti-Potassium channel Kv2.1 Antibody, clone L80/21

clone L80/21, from mouse

别名:

Potassium voltage-gated channel subfamily B member 1, Delayed rectifier potassium channel 1, DRK1, Voltage-gated potassium channel subunit Kv2.1

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关于此项目

UNSPSC代码:
12352203
eCl@ss:
32160702
NACRES:
NA.41
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生物来源

mouse

抗体形式

purified antibody

抗体产品类型

primary antibodies

克隆

L80/21, monoclonal

种属反应性

rat, mouse

技术

immunohistochemistry: suitable (paraffin)
western blot: suitable

同位素/亚型

IgG3κ

NCBI登记号

UniProt登记号

运输

wet ice

靶向翻译后修饰

unmodified

基因信息

mouse ... Kcnb1(16500)

一般描述

Voltage-gated potassium channel subunit Kv2.1 (Kv2.1) is also called potassium voltage-gated channel subfamily B member 1 (KCNB1) or delayed rectifier potassium channel 1 (DRK1). Kv2.1 is a voltage-gated potassium ion channel that is expressed in the brain (cell bodies and dendrites of neurons but not axons, as well as Schwann cells), atria, ventricle, skeletal muscle, cochlea, retina, lung and pulmonary arteries. It is involved in maintaining membrane potential and modulating electrical excitability of both neurons and muscle cells. It is thought that Kv2.1 has a role in the muscle tone of the pulmonary system, as the expression Kv2.1 in pulmonary smooth muscle has been found to be reduced in chronic hypoxic pulmonary hypertension.
~95 kDa observed

免疫原

Epitope: C-terminus
Linear peptide corresponding to the C-terminus of rat Potassium channel Kv2.1.

应用

Detect Kv2.1 using this mouse monoclonal antibody, Anti-Potassium channel Kv2.1 Antibody, clone L80/21 validated for use in western blotting & IHC (Paraffin).
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Potassium channel Kv2.1 in rat frontal cortex tissue.

Western Blotting Analysis: A representative lot detected Potassium channel Kv2.1 in wild type mouse brain membrane tissue lysate, and demonstrated a loss of signal in Potassium channel Kv2.1 knock out mouse brain membrante tissue lysate (Prof. J. Trimmer, University of California, Davis.).
Research Category
Neuroscience
Research Sub Category
Synapse & Synaptic Biology

生化/生理作用

This antibody recognizes the C-terminus of Potassium channel Kv2.1.

外形

Protein G Purified
Format: Purified
Purified mouse monoclonal IgG3κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

制备说明

Stable for 1 year at 2-8°C from date of receipt.

分析说明

Control
Rat brain tissue lysate
Evaluated by Western Blotting in rat brain tissue lysate.

Western Blotting Analysis: 1 µg/mL of this antibody detected Potassium channel Kv2.1 in 10 µg of rat brain tissue lysate.

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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储存分类代码

12 - Non Combustible Liquids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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