00920
N-乙酰基-L-天冬氨酸
≥99.0% (T)
别名:
(2S)-2-Acetamidobutanedioic acid, N-Acetyl-S-aspartic acid
质量水平
方案
≥99.0% (T)
表单
powder
旋光性
[α]20/D +12±1°, c = 2% in 6 M HCl
反应适用性
reaction type: solution phase peptide synthesis
颜色
colorless to white
mp
137-140 °C (lit.)
141-146 °C
应用
peptide synthesis
SMILES字符串
CC(=O)N[C@@H](CC(O)=O)C(O)=O
InChI
1S/C6H9NO5/c1-3(8)7-4(6(11)12)2-5(9)10/h4H,2H2,1H3,(H,7,8)(H,9,10)(H,11,12)/t4-/m0/s1
InChI key
OTCCIMWXFLJLIA-BYPYZUCNSA-N
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应用
N-乙酰基-L-天门冬氨酸可用作合成以下物质的反应物：
- 通过选择性还原和酸催化环化反应形成受保护的高丝氨酸γ-内酯。
- 通过环缩合形成外消旋氨基取代琥珀酰亚胺衍生物。
其他说明
综述；大脑中乙酰胆碱合成时的乙酰基供体。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
P Gideon et al.
Stroke, 23(11), 1566-1572 (1992-11-01)
The early time course after acute stroke of cerebral N-acetylaspartate, creatine and phosphocreatine, and compounds containing choline was studied in vivo by means of localized water-suppressed proton magnetic resonance spectroscopy. Eight patients with acute stroke were studied serially in the
Maria A Rocca et al.
NeuroImage, 18(4), 847-855 (2003-05-03)
Previous work has suggested that functional reorganization of cortical areas might have a role in limiting the clinical impact of axonal pathology in patients with established multiple sclerosis (MS). Since there is evidence for irreversible tissue damage even in patients
Emilie Chamard et al.
Neurosurgical focus, 33(6), E4: 1-E4: 7 (2012-12-04)
Despite negative neuroimaging findings using traditional neuroimaging methods such as MRI and CT, sports-related concussions have been shown to cause neurometabolic changes in both the acute and subacute phases of head injury. However, no prospective clinical study has used an
A Microwave-Assisted Synthesis of (S)-N-Protected Homoserine γ-Lactones from l-Aspartic Acid
Singh SP, et al.
The Journal of Organic Chemistry, 76(16), 6825-6831 (2011)
Paola Leone et al.
Science translational medicine, 4(165), 165ra163-165ra163 (2012-12-21)
Canavan disease is a hereditary leukodystrophy caused by mutations in the aspartoacylase gene (ASPA), leading to loss of enzyme activity and increased concentrations of the substrate N-acetyl-aspartate (NAA) in the brain. Accumulation of NAA results in spongiform degeneration of white
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