04936
O-(6-氯-1-苯并三氮唑-1-基)-N,N,N′,N′-四甲基脲六氟磷酸酯
≥98.0% (HPLC)
别名:
1-[双(二甲氨基)亚甲基]-5-氯苯并三唑鎓 3-氧化物六氟磷酸酯, N,N,N′,N′-四甲基-O-(6-氯-1H-苯并三氮唑-1-基)脲六氟磷酸酯, HCTU
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关于此项目
经验公式（希尔记法）:
C11H15ClF6N5OP
化学文摘社编号:
分子量:
413.69
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352101
MDL number:
InChI
1S/C11H15ClN5O.F6P/c1-15(2)11(16(3)4)18-17-10-7-8(12)5-6-9(10)13-14-17;1-7(2,3,4,5)6/h5-7H,1-4H3;/q+1;-1
SMILES string
ClC1=CC=C(N([C+](N(C)C)N(C)C)N=[N+]2[O-])C2=C1.F[P-](F)(F)(F)(F)F
InChI key
ZHHGTMQHUWDEJF-UHFFFAOYSA-N
assay
≥98.0% (HPLC)
form
powder
reaction suitability
reaction type: Coupling Reactions
impurities
≤0.5% water
mp
185-190 °C
application(s)
peptide synthesis
functional group
amine, chloro
Quality Level
Application
Reagent for:
Synthesis of near-infrared pH activatable fluorescent probes
Synthesis of human β-amyloid by Fmoc chemistry
Stereoselective Horner-Wadsworth-Emmons olefination
Covalent ligation of fluorescent peptides to quantum dots
Alkylation of human telomere sequence
Synthesis of near-infrared pH activatable fluorescent probes
Synthesis of human β-amyloid by Fmoc chemistry
Stereoselective Horner-Wadsworth-Emmons olefination
Covalent ligation of fluorescent peptides to quantum dots
Alkylation of human telomere sequence
Other Notes
固相载体上寡核苷酸串合成，用于生成多重寡核苷酸
signalword
Warning
hcodes
Hazard Classifications
Skin Sens. 1A
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Hyeran Lee et al.
Bioconjugate chemistry, 22(4), 777-784 (2011-03-11)
Highly tumor selective near-infrared (NIR) pH-activatable probe was developed by conjugating pH-sensitive cyanine dye to a cyclic arginine-glycine-aspartic acid (cRGD) peptide targeting α(v)β(3) integrin (ABIR), a protein that is highly overexpressed in endothelial cells during tumor angiogenesis. The NIR pH-sensitive
Fast conventional synthesis of human beta-amyloid (1-42) on the Symphony and Prelude.
German Fuentes et al.
Advances in experimental medicine and biology, 611, 173-174 (2009-04-30)
Wouter A van der Linden et al.
Organic & biomolecular chemistry, 8(8), 1885-1893 (2010-05-08)
The synthesis and biological evaluation of ten Michael acceptors containing potential proteasome inhibitors are described. Cellular targets of azide containing inhibitors and were assessed in HEK293T and RAW264.7 cells by a two step labeling strategy, followed by biotin-pulldown, affinity purification
Richard T Pon et al.
The Journal of organic chemistry, 67(3), 856-864 (2002-02-22)
More than one oligonucleotide can be synthesized at a time by linking multiple oligonucleotides end-to-end in a tandem manner on the surface of a solid-phase support. The 5'-terminal hydroxyl position of one oligonucleotide serves as the starting point for the
Gengo Kashiwazaki et al.
Bioorganic & medicinal chemistry, 18(8), 2887-2893 (2010-03-31)
We designed and synthesized human telomere alkylating N-methylpyrrole-N-methylimidazole (PI) polyamide conjugates (1-6). The C-type conjugates 1-3 possessed a chlorambucil moiety at the C terminus, whereas the N-type conjugates 4-6 had one of these moieties at the N terminus. The DNA
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