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Merck
CN

18081

倍他米松

≥95.0% (HPLC), pharmaceutical impurity standard

别名:

9α-氟-11β,17α,21-三羟基-16β-甲基孕甾-1,4-二烯-3,20-二酮, 9α-氟-16β-甲基-11β,17α,21-三羟基-1,4-孕甾二烯-3,20-二酮, 9α-氟-16β-甲基泼尼松龙

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关于此项目

经验公式（希尔记法）:
C22H29FO5
化学文摘社编号:
378-44-9
分子量:
392.46
UNSPSC Code:
41116107
PubChem Substance ID:
329751617
EC Number:
206-825-4
MDL number:
MFCD00062969

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grade

analytical standard

assay

≥95.0% (HPLC)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

impurities

≤10.0% related substances

loss

≤5.0% loss on drying

mp

235-237 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

[H][C@@]12C[C@H](C)[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]3(F)[C@@]2([H])CCC4=CC(=O)C=C[C@]34C

InChI

1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15-,16-,17-,19-,20-,21-,22-/m0/s1

InChI key

UREBDLICKHMUKA-DVTGEIKXSA-N

Gene Information

human ... NR3C1(2908)

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General description

Betamethasone is a corticosteroid predominantly used in patients with premature labor. It is also seen useful in reducing incidence of respiratory distress syndrome.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

pictograms

Health hazard
GHS08

signalword

Danger

Hazard Classifications

Repr. 1B - STOT RE 2

target_organs

Liver,Kidney,Endocrine system

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Briggs, Gerald G., Freeman, Roger K.,Yaffe, Sumner J.;
Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk, 140-140 (2011)
Simultaneous determination of dexamethasone and betamethasone in pharmaceuticals by reversed-phase HPLC
Santos-Montes, A., A. I. Gasco-Lopez, and R. Izquierdo-Hornillos.
Chromatographia, 39.9-10, 539-542 (1994)
Peter Roy Stutchfield et al.
Archives of disease in childhood. Fetal and neonatal edition, 98(3), F195-F200 (2013-02-21)
To determine whether antenatal betamethasone prior to elective term caesarean section (CS) affects long term behavioural, cognitive or developmental outcome, and whether the risk of asthma or atopic disease is reduced. A questionnaire based follow-up of a multicentre randomised controlled
Elizabeth V Asztalos et al.
JAMA pediatrics, 167(12), 1102-1110 (2013-10-16)
A single course of antenatal corticosteroid therapy is recommended for pregnant women at risk of preterm birth between 24 and 33 weeks' gestational age. However, 50% of women remain pregnant 7 to 14 days later, leading to the question of
Ran D Goldman
Canadian family physician Medecin de famille canadien, 59(1), 37-38 (2013-01-24)
Should I prescribe estrogen cream to treat labial adhesion in my prepubertal female patients? Many physicians offer young girls estrogen cream to be applied on the labia for several weeks to treat labial adhesion. While no randomized controlled trial data
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