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Merck
CN

20740

γ-丁内酯

puriss., ≥99.0% (GC)

别名:

γ-羟基丁酸内酯, 4-羟基丁酸内酯, GBL

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经验公式(希尔记法):
C4H6O2
化学文摘社编号:
分子量:
86.09
EC Number:
202-509-5
UNSPSC Code:
12352100
PubChem Substance ID:
Beilstein/REAXYS Number:
105248
MDL number:
Assay:
≥99.0% (GC)
Form:
liquid
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InChI key

YEJRWHAVMIAJKC-UHFFFAOYSA-N

InChI

1S/C4H6O2/c5-4-2-1-3-6-4/h1-3H2

SMILES string

O=C1CCCO1

vapor density

3 (vs air)

vapor pressure

1.5 mmHg ( 20 °C)

grade

puriss.

assay

≥99.0% (GC)

form

liquid

autoignition temp.

851 °F

expl. lim.

16 %

refractive index

n20/D 1.437

bp

204-205 °C (lit.)

mp

−45 °C (lit.)

density

1.12 g/mL at 25 °C (lit.)

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Biochem/physiol Actions

γ-羟基丁酸(GHB)前体。 可通过阻断多巴胺能神经元的脉冲流,抑制多巴胺释放。 γ-丁内酯预处理可用于检测自身受体诱导的多巴胺释放。
γ-羟基丁酸(GHB)前体;抑制多巴胺释放。

pictograms

CorrosionExclamation mark

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1 - STOT SE 3

target_organs

Central nervous system

存储类别

10 - Combustible liquids

wgk

WGK 1

flash_point_f

208.4 °F - closed cup

flash_point_c

98 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

法规信息

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分析证书(COA)

Lot/Batch Number

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Michelle Wood et al.
Journal of chromatography. A, 1056(1-2), 83-90 (2004-12-15)
We have developed a rapid method that enables the simultaneous analysis of gamma-hydroxybutyrate (GHB) and its precursors, i.e. gamma-butyrolactone (GBL) and 1,4-butanediol (1,4-BD) in urine. The method comprised a simple dilution of the urine sample, followed by liquid chromatography-tandem mass
Zheng-Yuan Su et al.
Chemical research in toxicology, 26(3), 477-485 (2013-02-28)
Cancer development has been linked to epigenetic modifications of cancer oncogenes and tumor suppressor genes; in advanced metastatic cancers, severe epigenetic modifications are present. We previously demonstrated that the progression of prostate tumors in TRAMP mice is associated with methylation
Christian Westendorf et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(10), 3853-3858 (2013-02-23)
The rapid reorganization of the actin cytoskeleton in response to external stimuli is an essential property of many motile eukaryotic cells. Here, we report evidence that the actin machinery of chemotactic Dictyostelium cells operates close to an oscillatory instability. When
Bo Xue et al.
Biochemistry, 52(13), 2359-2370 (2013-03-07)
The in vitro evolution and engineering of quorum-quenching lactonases with enhanced reactivities was achieved using a thermostable GKL enzyme as a template, yielding the E101G/R230C GKL mutant with increased catalytic activity and a broadened substrate range [Chow, J. Y., Xue
Axel Bidon-Chanal et al.
European journal of medicinal chemistry, 60, 479-489 (2013-01-29)
Glycogen synthase kinase 3β (GSK-3β) is widely recognised as a relevant player in the pathogenesis of several highly prevalent disorders such as Alzheimer's disease, mood disorders, diabetes and cancer. Therefore, this enzyme constitutes a highly attractive therapeutic target for the

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