95152
视黄酸
≥98.0% (HPLC), ~3300 U/mg
别名:
ATRA, 全反式维甲酸, 维生素A酸, 维甲酸
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关于此项目
经验公式（希尔记法）:
C20H28O2
化学文摘社编号:
分子量:
300.44
EC Number:
206-129-0
UNSPSC Code:
12352203
MDL number:
Beilstein/REAXYS Number:
2057223
InChI
1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+
InChI key
SHGAZHPCJJPHSC-YCNIQYBTSA-N
SMILES string
CC1=C(\C=C\C(C)=C\C=C\C(C)=C\C(O)=O)C(C)(C)CCC1
assay
≥98.0% (HPLC)
specific activity
~3300 U/mg
impurities
≤0.002% heavy metals
ign. residue
≤0.1% (as SO4)
loss
≤0.5% loss on drying
mp
180-181 °C (lit.), 182-186 °C
storage temp.
2-8°C
Gene Information
human ... RARA(5914), RARB(5915), RARG(5916)
Biochem/physiol Actions
全−反式−视黄酸（ATRA）是视黄酸受体（RAR）和视黄醇类 X 受体（RXR）的配体。所结合的RAR和RXR可作为调节正常细胞和恶性细胞的生长和分化的转录因子。细胞色素P450（CYP）可催化ATRA的4-羟基化。视黄酸可使胚胎干细胞成为神经元。
视黄酸受体（RAR）和类视黄醇X受体（RXR）的配体; 引发胚胎干细胞成为神经元。
Other Notes
1 U corresponds to 1 international U acc. to Ph Eur II, 217 (1983)
Review: Retinoic acid metabolism
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Repr. 1B - Skin Irrit. 2
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
Retinoic acid metabolism.
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