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BP616

雌酮硫酸酯哌嗪

Name: 雌酮硫酸酯哌嗪
Brand: SIAL

British Pharmacopoeia (BP) Reference Standard

别名:

3-(Sulfooxy)-estra-1,3,5(10)-trien-17-one : piperazine (1:1), Estrone sulfate piperazine salt, Harmogen, Ogen

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关于此项目

经验公式（希尔记法）:

C₁₈H₂₂O₅S·C₄H₁₀N₂

化学文摘社编号:

7280-37-7

分子量:

436.56

UNSPSC Code:

41116107

NACRES:

NA.24

MDL number:

MFCD00867399

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属性

grade

pharmaceutical primary standard

API family

estropipate

form

solid

shelf life

limited shelf life, expiry date on the label

manufacturer/tradename

application(s)

pharmaceutical
pharmaceutical small molecule

format

neat

storage temp.

2-8°C

SMILES string

C1CNCCN1.C[C@]23CC[C@H]4[C@@H](CCc5cc(OS(O)(=O)=O)ccc45)[C@@H]2CCC3=O

InChI

1S/C18H22O5S.C4H10N2/c1-18-9-8-14-13-5-3-12(23-24(20,21)22)10-11(13)2-4-15(14)16(18)6-7-17(18)19;1-2-6-4-3-5-1/h3,5,10,14-16H,2,4,6-9H2,1H3,(H,20,21,22);5-6H,1-4H2/t14-,15-,16+,18+;/m1./s1

InChI key

HZEQBCVBILBTEP-ZFINNJDLSA-N

Gene Information

human ... ESR1(2099)

说明

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Estropipate BP Reference standard, intended for use in laboratory tests only as specifically prescribed in the British Pharmacopoeia.

Biochem/physiol Actions

Estropipate is the piperazine salt of the estrogen receptor agonist estrone-3-sulfate and a potent, specific inhibitor of the organic anion transporting polypeptide 1B1 (OATP1B1, IC₅₀ = 60 nM).

Estropipate is the piperazine salt of the estrogen receptor agonist estrone-3-sulfate and a potent, specific inhibitor of the organic anion transporting polypeptide 1B1.

Packaging

Unit quantity: 100 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

Other Notes

Sales restrictions may apply.

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pictograms

GHS08,GHS07

signalword

Danger

hcodes

H302,H350

pcodes

P201 - P202 - P264 - P280 - P308 + P313 - P501

Hazard Classifications

Acute Tox. 4 Oral - Carc. 1A

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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分析证书(COA)

Lot/Batch Number

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Microglia Implicated in Tauopathy in the Striatum of Neurodegenerative Disease Patients from Genotype to Phenotype.

Huifangjie Li et al.

International journal of molecular sciences, 21(17) (2020-08-28)

We found interactions between dopamine and oxidative damage in the striatum involved in advanced neurodegeneration, which probably change the microglial phenotype. We observed possible microglia dystrophy in the striatum of neurodegenerative brains. To investigate the interactions between oxidative damage and

The interactions of dopamine and oxidative damage in the striatum of patients with neurodegenerative diseases.