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F0060000

Fenticonazole nitrate

Name: Fenticonazole nitrate
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

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关于此项目

经验公式（希尔记法）:

C₂₄H₂₁Cl₂N₃O₄S

化学文摘社编号:

73151-29-8

分子量:

518.41

MDL number:

MFCD00941391

UNSPSC Code:

41116107

NACRES:

NA.24

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属性

grade

pharmaceutical primary standard

API family

fenticonazole

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

S(c2ccc(cc2)COC(C[n]4cncc4)c3c(cc(cc3)Cl)Cl)c1ccccc1.[N+](=O)([O-])O

InChI

1S/C24H20Cl2N2OS.HNO3/c25-19-8-11-22(23(26)14-19)24(15-28-13-12-27-17-28)29-16-18-6-9-21(10-7-18)30-20-4-2-1-3-5-20;2-1(3)4/h1-14,17,24H,15-16H2;(H,2,3,4)

InChI key

FJNRUWDGCVDXLU-UHFFFAOYSA-N

说明

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Fenticonazole nitrate EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

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分析证书(COA)

Lot/Batch Number

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Fenticonazole nitrate for treatment of vulvovaginitis: efficacy, safety, and tolerability of 1-gram ovules, administered as ultra-short 2-day regimen.

J Fernández-Alba et al.

Journal of chemotherapy (Florence, Italy), 16(2), 179-186 (2004-06-26)

Because of its potential as a low cost first-line monotherapy for the most common vulvovaginal infections, we evaluated fenticonazole nitrate in a prospective, open-label, multicenter pilot study with 101 sexually active women (per-protocol; 16 to 61 years of age) with

Chiral discrimination by HPLC and CE and antifungal activity of racemic fenticonazole and its enantiomers.

M G Quaglia et al.

Chirality, 14(5), 449-454 (2002-05-02)

Fenticonazole is a chiral antifungal agent, used in therapy as the racemic mixture. The investigation on the chirality of fenticonazole is reported in this study. rac-Fenticonazole was resolved by HPLC and by capillary electrophoresis (CE). The chiral stationary phase (CSP)

Topical fenticonazole in dermatology and gynaecology: current role in therapy.

Stefano Veraldi et al.

Drugs, 68(15), 2183-2194 (2008-10-09)

Fenticonazole is an imidazole derivative with a broad spectrum of antimycotic activity against dermatophytes and yeasts in in vitro and clinical studies. Fenticonazole exerts its unique antimycotic mechanism of action in the following three ways: (i) inhibition of the secretion

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货号	GTIN
F0060000	04061833610732