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L0745000

洛莫司汀

Name: 洛莫司汀
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

别名:

1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea

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关于此项目

经验公式（希尔记法）:

C₉H₁₆ClN₃O₂

化学文摘社编号:

13010-47-4

分子量:

233.70

NACRES:

NA.24

PubChem Substance ID:

329817373

UNSPSC Code:

41116107

MDL number:

MFCD00012392

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属性

grade

pharmaceutical primary standard

API family

lomustine

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

ClCCN(N=O)C(=O)NC1CCCCC1

InChI

1S/C9H16ClN3O2/c10-6-7-13(12-15)9(14)11-8-4-2-1-3-5-8/h8H,1-7H2,(H,11,14)

InChI key

GQYIWUVLTXOXAJ-UHFFFAOYSA-N

说明

General description

Nitrosamines are chemical compounds that can form during drug manufacturing and may pose health risks, including carcinogenicity.

This product is provided as delivered and specified by the issuing Pharmacopoeia. For further information and support, including certificate/ product information sheets, please go to the website of the issuing Pharmacopoeia.

Application

Lomustine EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem/physiol Actions

Antineoplastic agent with cellular DNA effects. Lomustine induces p53 expression in A2870 cells.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

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pictograms

GHS06,GHS08

signalword

Danger

hcodes

H301,H350

pcodes

P201 - P301 + P310 + P330

Hazard Classifications

Acute Tox. 3 Oral - Carc. 1B

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Preliminary study of lomustine in the treatment of intracranial masses in dogs following localization by imaging techniques.

L M Fulton et al.

Seminars in veterinary medicine and surgery (small animal), 5(4), 241-245 (1990-11-01)

Treatment of advanced neuroendocrine tumours using combination chemotherapy with lomustine and 5-fluorouracil.

G A Kaltsas et al.

Clinical endocrinology, 57(2), 169-183 (2002-08-03)

Combination chemotherapy with the two agents streptozotocin (SZT), which is a nitrosurea, and 5-fluorouracil (5-FU), an alkylating agent, has a long-established role in the treatment of neuroendocrine tumours; however, it is often accompanied by considerable toxicity, and it has not

The role of an all-oral chemotherapy containing lomustine (CCNU) in advanced,fs progressive Hodgkin lymphoma: a patient-friendly palliative option which can result in long-term disease control.

S J Proctor et al.

Annals of oncology : official journal of the European Society for Medical Oncology, 21(2), 426-428 (2009-11-11)

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全球贸易项目编号

货号	GTIN
L0745000	04061833948989