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PHR1021

磷酸克林霉素

Name: 磷酸克林霉素
Brand: SIAL

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

克林霉素 2-磷酸酯

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关于此项目

经验公式（希尔记法）:

C₁₈H₃₄ClN₂O₈PS

化学文摘社编号:

24729-96-2

分子量:

504.96

NACRES:

NA.24

PubChem Substance ID:

329823052

UNSPSC Code:

41116107

EC Number:

246-433-0

MDL number:

MFCD07793328

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属性

Quality Level

300

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to Ph. Eur. C2269000, traceable to USP 1138008

API family

clindamycin

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

-10 to -25°C

SMILES string

CCC[C@@H]1C[C@H](N(C)C1)C(=O)NC([C@H](C)Cl)C2O[C@H](SC)[C@H](OP(O)(O)=O)[C@@H](O)[C@H]2O

InChI

1S/C18H34ClN2O8PS/c1-5-6-10-7-11(21(3)8-10)17(24)20-12(9(2)19)15-13(22)14(23)16(18(28-15)31-4)29-30(25,26)27/h9-16,18,22-23H,5-8H2,1-4H3,(H,20,24)(H2,25,26,27)/t9-,10+,11-,12?,13+,14-,15?,16+,18+/m0/s1

InChI key

UFUVLHLTWXBHGZ-MWBQRTRKSA-N

说明

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Clindamycin is a common antibiotic drug generally employed for the treatment of infections caused by gram-positive aerobes and both gram-negative and gram-positive anaerobic pathogens.

Application

Clindamycin Phosphate may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography and potentiometry techniques.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

Spectrum of Activity: Gram positive cocci and taxoplasma. Especially active against anaerobic bacteria.
Mode of Action: Inhibits protein synthesis in bacterial by binding the 50s ribosomal subunit.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.

Other Notes

Antibacterial and antiprotozoal antibiotic of the licosamide class.

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

To see an example of a Certificate of Analysis for this material enter LRAC4009 in the slot below. This is an example certificate only and may not be the lot that you receive.

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pictograms

GHS07

signalword

Warning

hcodes

H302,H317,H319,H362

pcodes

P260 - P263 - P280 - P301 + P312 - P302 + P352 - P308 + P313

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Lact. - Skin Sens. 1

存储类别

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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Nonisothermal stability assessment of stable pharmaceuticals: testing of a clindamycin phosphate formulation

Kipp JE and Hlavaty JJ

Pharmaceutical Research, 8(5), 570-575 (1991)

High-performance liquid chromatography of clindamycin antibiotics using tris (bipyridine)-ruthenium (III) chemiluminescence detection

Targove MA and Danielson ND

Journal of Chromatographic Science, 28(10), 505-509 (1990)

Sub-second adsorption for the fast sub-nanomolar monitoring of Clindamycin in its pure and pharmaceutical samples by fast Fourier transformation with the use of continuous cyclic voltammetry at an Au microelectrode in a flowing system

Norouzi P, et al.

Materials Science and Engineering, C, 28(1), 87-93 (2008)

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全球贸易项目编号

货号	GTIN
PHR1021-1G	04061835236930