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T1450000

马来酸替莫洛尔

Name: 马来酸替莫洛尔
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

别名:

噻吗洛尔马来酸盐, (S)-3-[3-(叔丁基氨基)-2-羟基丙氧基]-4-吗啉基-1,2,5-噻二唑马来酸盐马来酸盐, (S)-马来酸噻吗洛尔

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关于此项目

经验公式（希尔记法）:

C₁₃H₂₄N₄O₃S · C₄H₄O₄

化学文摘社编号:

26921-17-5

分子量:

432.49

NACRES:

NA.24

PubChem Substance ID:

329826674

UNSPSC Code:

41116107

MDL number:

MFCD00058356

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属性

grade

pharmaceutical primary standard

API family

timolol

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

[H]\C(=C(/[H])C(O)=O)C(O)=O.CC(C)(C)NC[C@H](O)COc1nsnc1N2CCOCC2

InChI

1S/C13H24N4O3S.C4H4O4/c1-13(2,3)14-8-10(18)9-20-12-11(15-21-16-12)17-4-6-19-7-5-17;5-3(6)1-2-4(7)8/h10,14,18H,4-9H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t10-;/m0./s1

InChI key

WLRMANUAADYWEA-NWASOUNVSA-N

Gene Information

human ... ADRB1(153), ADRB2(154)

说明

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Timolol maleate EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

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pictograms

GHS08,GHS07

signalword

Warning

hcodes

H302,H361

pcodes

P201 - P202 - P264 - P270 - P301 + P312 - P308 + P313

Hazard Classifications

Acute Tox. 4 Oral - Repr. 2

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

监管及禁止进口产品

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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In vivo assessment of aqueous humor dynamics upon chronic ocular hypertension and hypotensive drug treatment using gadolinium-enhanced MRI.

Leon C Ho et al.

Investigative ophthalmology & visual science, 55(6), 3747-3757 (2014-04-26)

Although glaucoma treatments alter aqueous humor (AH) dynamics to lower intraocular pressure, the regulatory mechanisms of AH circulation and their contributions to the pathogenesis of ocular hypertension and glaucoma remain unclear. We hypothesized that gadolinium-enhanced magnetic resonance imaging (Gd-MRI) can

Comparison of dorzolamide/timolol versus brimonidine/timolol fixed combination therapy in the management of steroid-induced ocular hypertension.

Göktuğ Seymenoğlu et al.

Journal of glaucoma, 24(2), 111-116 (2013-06-29)

To compare the efficacy of fixed combinations of dorzolamide-timolol (FCDT) and brimonidine-timolol (FCBT) in patients with intraocular pressure (IOP) elevations after intravitreal triamcinolone acetonide (IVTA) injections. This was a prospective, randomized, open-label study. Patients who received IVTA injections due to

The transcorneal penetration of commercial ophthalmic formulations containing timolol maleate in rabbit eyes.

Masamichi Fukuda et al.

Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 31(1), 57-60 (2014-10-11)

We investigated the transcorneal penetration of commercial ophthalmic formulations containing timolol maleate in rabbit eyes. One drop (30 μL) of each ophthalmic solution (Xalacom(®), DuoTrav(®), Cosopt(®), and Timoptol(®)) was administered to the conjunctival sac of the rabbits' eyes and the

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货号	GTIN
T1450000	04061838581648