grade
pharmaceutical primary standard
API family
acebutolol
manufacturer/tradename
EDQM
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-8°C
SMILES string
N(C(C)C)CC(O)COc1c(cc(cc1)NC(=O)C)C(=O)C
InChI
1S/C16H24N2O4/c1-10(2)17-8-14(21)9-22-16-6-5-13(18-12(4)20)7-15(16)11(3)19/h5-7,10,14,17,21H,8-9H2,1-4H3,(H,18,20)
InChI key
AWOGXJOBNAWQSF-UHFFFAOYSA-N
General description
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.
Application
Acebutolol impurity B EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.
Packaging
The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.
Other Notes
Sales restrictions may apply.
M J Boutroy et al.
European journal of clinical pharmacology, 30(6), 737-739 (1986-01-01)
The concentrations of acebutolol and of its main active metabolite diacetolol in milk and plasma were studied in 7 hypertensive mothers treated with acebutolol, a cardioselective beta-adrenoceptor blocking agent. Clinical monitoring on their newborn babies was also done, as well
Separation of acebutolol and diacetolol diastereomers by reversed-phase high-performance liquid chromatography.
A A Gulaid et al.
Journal of chromatography, 318(2), 393-397 (1985-01-18)
Jun Shik Choi et al.
Archives of pharmacal research, 25(4), 541-545 (2002-09-07)
Pharmacokinetic characteristics of acebutolol and its main metabolite, diacetolol, following a single 10 mg/kg oral dose, were investigated in rabbits with carbon tetrachloride-induced hepatic failure. Plasma concentrations of acebutolol and diacetolol were determined by a high performance liquid chromatography assay.
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| Y0000359 | 04061833816370 |