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Merck
CN

Y0000471

用于系统适应性的丁螺环酮

European Pharmacopoeia (EP) Reference Standard

别名:

丁螺环酮盐酸盐 盐酸盐, N-[4-[4-(2-嘧啶基)-1-哌嗪基] 丁基]-8-氮杂螺[4.5]癸烷-7,9-二酮 盐酸盐

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关于此项目

经验公式(希尔记法):
C21H31N5O2 · HCl
化学文摘社编号:
分子量:
421.96
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
MDL number:
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grade

pharmaceutical primary standard

API family

buspirone

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

Cl[H].O=C1CC2(CCCC2)CC(=O)N1CCCCN3CCN(CC3)c4ncccn4

InChI

1S/C21H31N5O2.ClH/c27-18-16-21(6-1-2-7-21)17-19(28)26(18)11-4-3-10-24-12-14-25(15-13-24)20-22-8-5-9-23-20;/h5,8-9H,1-4,6-7,10-17H2;1H

InChI key

RICLFGYGYQXUFH-UHFFFAOYSA-N

Gene Information

human ... HTR1A(3350)

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Buspirone for system suitability EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem/physiol Actions

5-HT 1A 血清素受体激动剂;抗焦虑药。

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.


pictograms

Skull and crossbones

signalword

Danger

hcodes

Hazard Classifications

Acute Tox. 3 Oral

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Jan Tack et al.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 10(11), 1239-1245 (2012-07-21)
Impaired accommodation and hypersensitivity to gastric distention are believed to be involved in the development of functional dyspepsia (FD). Buspirone, a 5-hydroxytryptamine 1A receptor agonist, relaxes the proximal stomach in healthy individuals. We studied the effects of buspirone on symptoms
Hedayat Nazari et al.
Archives of gynecology and obstetrics, 287(3), 469-472 (2012-10-18)
The premenstrual syndrome (PMS), which causes emotional and physical symptoms, is a common problem in many women in their reproductive age. Many approaches to PMS with controversial results are available. The present study was performed to compare fluoxetine and buspirone
D F Avgustinovich et al.
Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 98(6), 693-705 (2012-09-28)
The influence of acute and chronic (14 days) buspirone administration (1 mg/kg, intraperitoneally) on the behavior of C57BL/6J female mice, being in social discomfort, were studied. The conditions of social discomfort include the permanent habitation of females in the cage



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货号GTIN
Y000047104061837568671