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Y0000609

2-氯-2′-脱氧腺苷

Name: 2-氯-2′-脱氧腺苷
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

别名:

2-Chloro-2′-deoxyadenosine, CdA, Cladribine

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关于此项目

经验公式（希尔记法）:

C₁₀H₁₂ClN₅O₃

化学文摘社编号:

4291-63-8

分子量:

285.69

NACRES:

NA.24

PubChem Substance ID:

329831048

UNSPSC Code:

41116107

MDL number:

MFCD00153939

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属性

grade

pharmaceutical primary standard

API family

cladribine

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

Nc1nc(Cl)nc2n(cnc12)[C@H]3C[C@H](O)[C@@H](CO)O3

InChI

1S/C10H12ClN5O3/c11-10-14-8(12)7-9(15-10)16(3-13-7)6-1-4(18)5(2-17)19-6/h3-6,17-18H,1-2H2,(H2,12,14,15)/t4-,5+,6+/m0/s1

InChI key

PTOAARAWEBMLNO-KVQBGUIXSA-N

说明

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Cladribine for peak identification EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

pictograms

GHS06,GHS08

signalword

Danger

hcodes

H301,H341,H361fd,H372

pcodes

P202 - P260 - P264 - P280 - P301 + P310 - P405

Hazard Classifications

Acute Tox. 3 Oral - Muta. 2 - Repr. 2 - STOT RE 1

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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2-Chlorodeoxyadenosine (cladribine) induces apoptosis in human monocyte-derived dendritic cells.

V Singh et al.

Clinical and experimental immunology, 173(2), 288-297 (2013-04-24)

2-Chlorodeoxyadenosine (cladribine, CdA) is an immunosuppressive drug that is licensed to treat hairy cell leukaemia, and has been shown recently to have beneficial effects in patients with multiple sclerosis (MS). The therapeutic effects of CdA have been suggested to be

Clinical characteristics and long-term outcome of young hairy cell leukemia patients treated with cladribine: a single-institution series.

Joshua D Rosenberg et al.

Blood, 123(2), 177-183 (2013-11-07)

Hairy cell leukemia (HCL) is a rare, indolent B-cell disorder in which single courses of cladribine induce high rates of complete responses. We report on 88 young HCL patients (≤40 years of age at diagnosis) treated with cladribine from the

Fludarabine and cladribine induce changes in surface proteins on human B-lymphoid cell lines involved with apoptosis, cell survival, and antitumor immunity.

Philippa L Kohnke et al.

Journal of proteome research, 11(9), 4436-4448 (2012-07-31)

Fludarabine and cladribine are purine analogues used to treat hematological malignancies. Alone or in combination with therapeutic antibodies, they are effective in treating patients with chronic lymphocytic leukemia and non-Hodgkin's lymphoma. However, the mechanisms of action of these drugs are

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货号	GTIN
Y0000609	04061835123551