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Y0001094

醋氯芬酸

Name: 醋氯芬酸
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

别名:

Aceclofenac, 2-[(2,6-Dichlorophenyl)amino]benzeneacetic acid carboxymethyl ester;

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关于此项目

经验公式（希尔记法）:

C₁₆H₁₃Cl₂NO₄

化学文摘社编号:

89796-99-6

分子量:

354.18

NACRES:

NA.24

PubChem Substance ID:

329831261

UNSPSC Code:

41116107

MDL number:

MFCD00864296

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属性

grade

pharmaceutical primary standard

API family

aceclofenac

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

OC(=O)COC(=O)Cc1ccccc1Nc2c(Cl)cccc2Cl

InChI

1S/C16H13Cl2NO4/c17-11-5-3-6-12(18)16(11)19-13-7-2-1-4-10(13)8-15(22)23-9-14(20)21/h1-7,19H,8-9H2,(H,20,21)

InChI key

MNIPYSSQXLZQLJ-UHFFFAOYSA-N

Gene Information

human ... PTGS2(5743)

说明

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Aceclofenac for peak identification EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem/physiol Actions

Non-steroidal, anti-inflammatory drug (NSAID), with selectivity for COX-2 over COX-1.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

pictograms

GHS06,GHS09

signalword

Danger

hcodes

H301,H319,H410

pcodes

P264 - P273 - P280 - P301 + P310 - P305 + P351 + P338 - P337 + P313

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Mixed micelle formation with hydrophobic and hydrophilic Pluronic block copolymers: implications for controlled and targeted drug delivery.

S S Kulthe et al.

Colloids and surfaces. B, Biointerfaces, 88(2), 691-696 (2011-08-25)

Pluronic block copolymers offer affluent phase behavioral characteristics and are extensively investigated for drug delivery applications. Hydrophobic Pluronics produce larger aggregates whereas hydrophilic Pluronics often generate small-sized micelles in aqueous milieu. To overcome the limitations and combine the advantages of

Preparation and in vitro in vivo evaluation of aceclofenac loaded alginate microspheres: an investigation of effects of polymer using multiple comparison analysis.

Madhusmruti Khandai et al.

Current drug delivery, 9(5), 495-505 (2012-04-24)

The aim of this present research work was to prepare and evaluate alginate microspheres of aceclofenac by ionic gelation method for targeting the drug release in intestinal region and decrease distinct tissue protection in the stomach. This method offers to

Single dose oral aceclofenac for postoperative pain in adults.

R Andrew Moore et al.

The Cochrane database of systematic reviews, (3)(3), CD007588-CD007588 (2009-07-10)

Aceclofenac is the prodrug of the non-steroidal anti-inflammatory drug (NSAID) diclofenac, widely used to treat acute and chronic pain. There are no known systematic reviews of its analgesic efficacy in acute postoperative pain. This review sought to evaluate the efficacy

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货号	GTIN
Y0001094	04061833796979