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Y0001657

喹硫平

Name: 喹硫平
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

别名:

喹硫平半富马酸盐, 2-[2-（4-二苯并[b，f] [1,4]硫氮杂-11-基-1-哌嗪基）乙氧基]乙醇半富马酸盐, 喹硫平富马酸盐

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关于此项目

经验公式（希尔记法）:

C₂₁H₂₅N₃O₂S · 0.5C₄H₄O₄

化学文摘社编号:

111974-72-2

分子量:

441.54

NACRES:

NA.24

PubChem Substance ID:

329831527

UNSPSC Code:

41116107

MDL number:

MFCD03423782

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属性

grade

pharmaceutical primary standard

API family

quetiapine

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

OC(=O)\C=C\C(O)=O.OCCOCCN1CCN(CC1)C2=Nc3ccccc3Sc4ccccc24.OCCOCCN5CCN(CC5)C6=Nc7ccccc7Sc8ccccc68

InChI

1S/2C21H25N3O2S.C4H4O4/c2*25-14-16-26-15-13-23-9-11-24(12-10-23)21-17-5-1-3-7-19(17)27-20-8-4-2-6-18(20)22-21;5-3(6)1-2-4(7)8/h2*1-8,25H,9-16H2;1-2H,(H,5,6)(H,7,8)/b;;2-1+

InChI key

ZTHJULTYCAQOIJ-WXXKFALUSA-N

Gene Information

human ... DRD2(1813), HTR2A(3356), HTR2C(3358)

说明

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Quetiapine fumarate EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem/physiol Actions

喹硫平半富马酸盐是一种联合血清素（5HT2）和多巴胺（D2）受体拮抗剂。

喹硫平半富马酸盐是一种非典型抗精神病药，一种联合血清素（5HT2）和多巴胺（D2）受体拮抗剂。

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

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存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Quetiapine for the treatment of cocaine use disorder.

Andre Tapp et al.

Drug and alcohol dependence, 149, 18-24 (2015-02-16)

Cocaine addiction continues to be a significant healthcare issue, yet there are no FDA approved medications for the treatment of cocaine use disorder within the United States. This 12-week, prospective, double-blind, randomized, placebo-controlled study examined the effectiveness of quetiapine (Seroquel

Evaluation of human D-amino acid oxidase inhibition by anti-psychotic drugs in vitro.

Miho Shishikura et al.

Bioscience trends, 8(3), 149-154 (2014-07-18)

It is of importance to determine whether antipsychotic drugs currently prescribed for schizophrenia exert D-amino acid oxidase (DAO)-inhibitory effects. We first investigated whether human (h)DAO can metabolize D-kynurenine (D-KYN) to produce the fluorescent compound kynurenic acid (KYNA) by using high-performance

An understanding of modified release matrix tablets behavior during drug dissolution as the key for prediction of pharmaceutical product performance - case study of multimodal characterization of quetiapine fumarate tablets.

Piotr Kulinowski et al.

International journal of pharmaceutics, 484(1-2), 235-245 (2015-02-24)

Motivation for the study was the lack of dedicated and effective research and development (R&D) in vitro methods for oral, generic, modified release formulations. The purpose of the research was to assess multimodal in vitro methodology for further bioequivalence study

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全球贸易项目编号

货号	GTIN
Y0001657	04061833798133