H5395
氢化可的松 17-戊酸酯
analytical standard
别名:
11β,17,21-Trihydroxypregn-4-ene-3,20-dione 17-valerate, Cortisol 17-valerate
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关于此项目
经验公式（希尔记法）:
C26H38O6
化学文摘社编号:
分子量:
446.58
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
260-786-8
MDL number:
InChI key
FZCHYNWYXKICIO-FZNHGJLXSA-N
InChI
1S/C26H38O6/c1-4-5-6-22(31)32-26(21(30)15-27)12-10-19-18-8-7-16-13-17(28)9-11-24(16,2)23(18)20(29)14-25(19,26)3/h13,18-20,23,27,29H,4-12,14-15H2,1-3H3/t18-,19-,20-,23+,24-,25-,26-/m0/s1
SMILES string
[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]4(C)[C@@]2([H])CC[C@]4(OC(=O)CCCC)C(=O)CO
grade
analytical standard
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
application(s)
clinical testing
format
neat
Quality Level
Gene Information
human ... NR3C1(2908)
Application
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Erythematous patches and plaques on the chest with induration of the breasts. Metastatic papillary RCC in dermal lymphatics.
Yevgeniy Balagula et al.
Archives of dermatology, 147(10), 1215-1220 (2011-10-19)
J Sefton et al.
Clinical therapeutics, 6(3), 282-293 (1984-01-01)
Evaluations of the comparative efficacy and safety of hydrocortisone valerate 0.2% ointment were made in six double-blind, multicenter trials involving a total of 485 patients, 209 with atopic dermatitis and 276 with plaque psoriasis. The vasoconstrictor activity of hydrocortisone valerate
K M Tramposch
Inflammation, 17(5), 531-536 (1993-10-01)
Synthetic glucocorticosteroids are widely used in clinical dermatology in the treatment of a number of inflammatory skin disorders. However, cutaneous side effects such as induction of skin atrophy are among the factors that limit the chronic use of this class
J Sefton et al.
Cutis, 32(1), 89-91 (1983-07-01)
Evaluations of the comparative efficacy and safety of a newly developed emollient ointment formulation of hydrocortisone valerate 0.2 percent were made in two double-blind, multicenter trials involving 145 patients with atopic dermatitis. Data are presented which indicate that hydrocortisone valerate
J G Alford et al.
Agents and actions, 37(3-4), 260-267 (1992-11-01)
We have previously shown that multiple topical applications, over 11 days, of the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) induces a persistent inflammatory reaction characterized by edema, cell infiltration and epidermal hyperplasia. In order to characterize the cell infiltrate during the establishment
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