M1511
2-巯基乙磺酸钠
analytical standard, ≥98.0% (titration)
别名:
2-巯基乙磺酸 钠盐, HS-CoM Na, MESNA, 辅酶 M 钠盐
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关于此项目
线性分子式:
HSCH2CH2SO3Na
化学文摘社编号:
分子量:
164.18
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
EC Number:
243-285-9
Beilstein/REAXYS Number:
3657828
MDL number:
InChI
1S/C2H6O3S2.Na/c3-7(4,5)2-1-6;/h6H,1-2H2,(H,3,4,5);/q;+1/p-1
InChI key
XOGTZOOQQBDUSI-UHFFFAOYSA-M
SMILES string
[Na+].[O-]S(=O)(=O)CCS
grade
analytical standard
assay
≥98.0% (titration)
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
application(s)
clinical testing
format
neat
Quality Level
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Application
此分析标准品也可用于以下用途：
- 通过胶束电动色谱 (MEKC)联用UV检测和MESNA毛细管衍生化，定量分析人体样品中的2-巯基乙磺酸钠 (MESNA)
- 开发荧光增强组氨酸稳定金纳米团簇(His-Au NCs)探针，检测美司钠（Uromitexan）样品中的2-巯基乙磺酸钠
- 高效液相色谱-串联质谱法生物分析大鼠血浆样品中的2-巯基乙磺酸钠
- 以金胶体为探针，通过表面增强拉曼散射(SERS)法定量分析两种药物制剂（注射剂）中的2-巯基乙磺酸钠
General description
2-巯基乙烷磺酸钠(Sodium 2-mercaptoethanesulfonate)是一种硫醇化合物，常用作减轻抗癌药物副作用的辅助药物，如氧氮磷环、环磷酰胺和异环磷酰胺。它可与药物的有毒代谢物（如丙烯醛）反应，形成无毒化合物。
Other Notes
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signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
P Pramanik et al.
Chemosphere, 90(2), 873-876 (2012-08-14)
Methanogens utilize simple carbon compounds to produce methane (CH(4)) under strictly anaerobic condition. During methanogenesis, methyl coenzyme M (MeCoM) is reduced by MeCoM reductase enzyme to CH(4) involving a nickel-containing cofactor F(430). In this experiment, strong chelating agent like ethylenediaminetetraacetic
Astrid Hoeppner et al.
Acta crystallographica. Section D, Biological crystallography, 68(Pt 11), 1549-1557 (2012-10-24)
The zinc-containing corrinoid:coenzyme M methyltransferase MtaA is part of the methanol-coenzyme M-methyltransferase complex of Methanosarcina mazei. The whole complex consists of three subunits: MtaA, MtaB and MtaC. The MtaB-MtaC complex catalyses the cleavage of methanol (bound to MtaB) and the
John T Mullen et al.
Cancer, 118(15), 3758-3765 (2011-12-20)
Patients with large, high-grade, extremity soft tissue sarcomas (STS) are at significant risk for distant recurrence and death. A regimen of preoperative chemotherapy consisting of mesna, Adriamycin (doxorubicin), ifosfamide, and dacarbazine (MAID), interdigitated with radiotherapy (RT) and followed by resection
Erdal Resit Yilmaz et al.
Acta neurochirurgica, 155(1), 141-149 (2012-10-12)
The agent, 2-mercaptoethane sulfonate (MESNA), is a synthetic small molecule, widely used as a systemic protective agent against chemotherapy toxicity, but is primarily used to reduce hemorrhagic cystitis induced by cyclophosphamide. Because MESNA has potential antioxidant and cytoprotective effects, so
Jun-ichi Nishigaki et al.
Inorganic chemistry, 51(6), 3690-3697 (2012-03-10)
Divalent and trivalent nickel complexes of 1,4,8,11-tetraazacyclotetradecane, denoted as cyclam hereafter, coordinated by methyl coenzyme M (MeSCoM(-)) and coenzyme M (HSCoM(-)) have been synthesized in the course our model studies of methyl coenzyme M reductase (MCR). The divalent nickel complexes
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