O0150000
奥美拉唑
European Pharmacopoeia (EP) Reference Standard
别名:
5-甲氧基-2 - [[（4-甲氧基-3，5-二甲基-2-吡啶基）甲基]亚磺酰基] -1H-苯并咪唑, Antra, Losec
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关于此项目
经验公式（希尔记法）:
C17H19N3O3S
CAS Number:
分子量:
345.42
MDL编号:
UNSPSC代码:
41116107
PubChem化学物质编号:
NACRES:
NA.24
等级
pharmaceutical primary standard
API类
omeprazole
制造商/商品名称
EDQM
技术
HPLC: suitable
gas chromatography (GC): suitable
应用
pharmaceutical (small molecule)
包装形式
neat
SMILES字符串
COc1ccc2[nH]c(nc2c1)S(=O)Cc3ncc(C)c(OC)c3C
InChI
1S/C17H19N3O3S/c1-10-8-18-15(11(2)16(10)23-4)9-24(21)17-19-13-6-5-12(22-3)7-14(13)20-17/h5-8H,9H2,1-4H3,(H,19,20)
InChI key
SUBDBMMJDZJVOS-UHFFFAOYSA-N
基因信息
human ... ATP4A(495), ATP4B(496)
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一般描述
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.
应用
Omeprazole EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.
包装
The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.
其他说明
Sales restrictions may apply.
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral - Aquatic Chronic 2 - Skin Sens. 1
储存分类代码
11 - Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Kazuhiro Shiizaki et al.
Molecular pharmacology, 85(2), 279-289 (2013-11-23)
Omeprazole (OME) induces the expression of genes encoding drug-metabolizing enzymes, such as CYP1A1, via activation of the aryl hydrocarbon receptor (AhR) both in vivo and in vitro. However, the precise mechanism of OME-mediated AhR activation is still under investigation. While
Anju Nohria et al.
Journal of the American Heart Association, 3(1), e000609-e000609 (2014-01-07)
Inflammation is fundamental to the development of atherosclerosis. We examined the effect of anti-inflammatory doses of salicylate on endothelium-dependent vasodilation, a biomarker of cardiovascular risk, in a broad range of subjects. We performed a randomized, double-blind, placebo-controlled crossover trial evaluating
R P Myers et al.
The American journal of gastroenterology, 96(12), 3428-3431 (2002-01-05)
Omeprazole is a proton pump inhibitor that is used commonly in the treatment of acid-peptic disorders. Although omeprazole is generally well tolerated, serious adverse effects such as renal failure have been reported. Thus far, 17 cases of acute interstitial nephritis
J Dent
Alimentary pharmacology & therapeutics, 17 Suppl 1, 5-9 (2003-03-05)
Plasma concentration measurements have confirmed that the advantageous hepatic metabolism of esomeprazole results in a greater delivery of acid suppressant to the systemic circulation, compared with an equal dose of omeprazole. Also, this superior delivery has been shown to cause
Vaibhav Mishra et al.
Phytomedicine : international journal of phytotherapy and phytopharmacology, 20(6), 506-511 (2013-03-07)
In continuation of our drug discovery program on Indian medicinal plants, the gastro protective mechanism of chebulinic acid isolated from Terminalia chebula fruit was investigated. Chebulinic acid was evaluated against cold restraint (CRU), aspirin (AS), alcohol (AL) and pyloric ligation
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