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文件

O0150000

奥美拉唑

Name: 奥美拉唑
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

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别名:

5-甲氧基-2 - [[（4-甲氧基-3，5-二甲基-2-吡啶基）甲基]亚磺酰基] -1H-苯并咪唑, Antra, Losec

经验公式（希尔记法）:

C₁₇H₁₉N₃O₃S

CAS号:

73590-58-6

分子量:

345.42

MDL编号:

MFCD00083192

PubChem化学物质编号:

329818823

NACRES:

NA.24

等级

pharmaceutical primary standard

API类

omeprazole

制造商/商品名称

EDQM

技术

HPLC: suitable
gas chromatography (GC): suitable

应用

pharmaceutical (small molecule)

格式

neat

SMILES字符串

COc1ccc2[nH]c(nc2c1)S(=O)Cc3ncc(C)c(OC)c3C

InChI

1S/C17H19N3O3S/c1-10-8-18-15(11(2)16(10)23-4)9-24(21)17-19-13-6-5-12(22-3)7-14(13)20-17/h5-8H,9H2,1-4H3,(H,19,20)

InChI key

SUBDBMMJDZJVOS-UHFFFAOYSA-N

基因信息

human ... ATP4A(495) , ATP4B(496)

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一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

应用

Omeprazole EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

包装

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

其他说明

Sales restrictions may apply.

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PHR1987

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PHR1989

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PHR1954

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PHR9054

2-氯甲基-4-甲氧基-3,5-二甲基吡啶盐酸盐, certified reference material, TraceCERT^®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

PHR2329

象形图

GHS07,GHS09

警示用语：

Warning

危险声明

H302 - H317 - H411

预防措施声明

P261 - P264 - P273 - P280 - P301 + P312 - P302 + P352

危险分类

Acute Tox. 4 Oral - Aquatic Chronic 2 - Skin Sens. 1

储存分类代码

11 - Combustible Solids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

分析证书(COA)

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示例

T1503

货号

25G

包装规格/数量

其它示例：

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

输入内容 1.000309185)

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Twice a day quadruple therapy for the first-line treatment of Helicobacter pylori in an area with a high prevalence of background antibiotic resistance.

Aydin Seref Köksal et al.

Acta gastro-enterologica Belgica, 76(1), 34-37 (2013-05-09)

Bismuth-containing quadruple therapy given four times a day is effective in the first-line treatment of Helicobacter pylori. We aimed to investigate whether twice daily posology could eradicate H. pylori at a comparable rate in an area with a high prevalence

A proton-pump inhibitor expedition: the case histories of omeprazole and esomeprazole.

Lars Olbe et al.

Nature reviews. Drug discovery, 2(2), 132-139 (2003-02-04)

Identification of amino acid residues in the ligand-binding domain of the aryl hydrocarbon receptor causing the species-specific response to omeprazole: possible determinants for binding putative endogenous ligands.

Kazuhiro Shiizaki et al.

Molecular pharmacology, 85(2), 279-289 (2013-11-23)

Omeprazole (OME) induces the expression of genes encoding drug-metabolizing enzymes, such as CYP1A1, via activation of the aryl hydrocarbon receptor (AhR) both in vivo and in vitro. However, the precise mechanism of OME-mediated AhR activation is still under investigation. While

Proton pump inhibitors decrease eotaxin-3 expression in the proximal esophagus of children with esophageal eosinophilia.

Jason Y Park et al.

PloS one, 9(7), e101391-e101391 (2014-07-06)

Besides reducing gastric acid secretion, proton pump inhibitors (PPIs) suppress Th2-cytokine-stimulated expression of an eosinophil chemoattractant (eotaxin-3) by esophageal epithelial cells through acid-independent, anti-inflammatory mechanisms. To explore acid-inhibitory and acid-independent, anti-inflammatory PPI effects in reducing esophageal eosinophilia, we studied eotaxin-3

Acute interstitial nephritis due to omeprazole.

R P Myers et al.

The American journal of gastroenterology, 96(12), 3428-3431 (2002-01-05)

Omeprazole is a proton pump inhibitor that is used commonly in the treatment of acid-peptic disorders. Although omeprazole is generally well tolerated, serious adverse effects such as renal failure have been reported. Thus far, 17 cases of acute interstitial nephritis

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